Sökning: "prime-boost"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet prime-boost.

  1. 1. Prime-boost immunization strategies against HIV-1

    Författare :Andreas Bråve; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Since the start of the global HIV epidemic in 1981, more than twentyfive million people have succumbed to AIDS-related diseases. The epidemic is most severe in Sub-Saharan Africa, where twentyfive million people are currently infected and more than two million died during 2006. LÄS MER

  3. 2. Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity

    Författare :Erik Rollman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; DNA-vaccine; gp 160; GM-CSF; HPV 16 L OBS I; MuLV; prime-boost;

    Sammanfattning : On April 23, 1984, the prominent scientist Robert Gallo held a historical press conference at the Department of Health and Human Services, Washington D.C., USA. He announced that his laboratory at the National Institutes of Health had over the last months isolated a retrovirus named Human T-cell Leukemia Virus type III (HTLV-III). LÄS MER

  4. 3. Alphavirus replicon-based strategies for vaccination

    Författare :Maria Lisa Knudsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Vaccination has been extremely successful for the control of many infectious diseases. However, efficient vaccines are still not available against diseases such as HIV, hepatitis C, malaria and tuberculosis. For these diseases, the traditional vaccine approaches are not feasible, and thus new vaccine technologies are needed. LÄS MER

  5. 4. HIV-2 and SIV vaccine studies in macaques : with emphasis on humoral immune responses

    Författare :Charlotta Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Vaccines; HIV-2; SIV; macaques; adjuvant; immune response; antibodies; neutralising antibodies; cell-mediated immunity; T-cell proliferation; CTL;

    Sammanfattning : This thesis describes the evaluation of HIV vaccines candidates in the HIV-2 or SIV monkey models. The immunogenicity and protective efficacy of the vaccines were investigated. Furthermore, correlates to protective immunity were sought. LÄS MER

  7. 5. Viral vectors, in innate and adaptive immunity

    Författare :Tanja I Näslund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recombinant viral vectors and DNA vectors induce strong immune responses in animal models. However, in clinical trials, the generation of immune responses is less robust, suggesting that further optimization and a deeper understanding of nucleic acid-based vaccines are required. LÄS MER