Sökning: "preparative chromatography"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden preparative chromatography.

  1. 1. Adsorption Studies with Liquid Chromatography : Experimental Preparations for Thorough Determination of Adsorption Data

    Författare :Lena Edström; Jonas Bergquist; Lars Hagel; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Liquid chromatography; HPLC; UHPLC; Reversed phase; Preparative chromatography; Adsorption isotherm; Injection profile; Sample pH; pH stable conditions; Peak deformation; Band distortion; Overloaded band; Chiral preparative chromatography; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : Analytical chemistry is a field with a vast variety of applications. A robust companion in the field is liquid chromatography, the method used in this thesis, which is an established workhorse and a versatile tool in many different disciplines. LÄS MER

  3. 2. Design of robust preparative chromatography

    Författare :Marcus Degerman; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; sensitivity analysis; optimization; modeling; preparative chromatography; Design space; Control Space; uncertainty analysis;

    Sammanfattning : This work presents a methodology for analyzing and optimizing preparative chromatographic processes. It uses a model-based approach to find the critical process parameters, analyze the control space and suggest a design space that can be registered with the regulatory agencies. LÄS MER

  4. 3. Modeling and Calibration of Preparative Chromatography

    Författare :Niklas Borg; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chromatography; Modeling; Simulation; Calibration; Model based analysis;

    Sammanfattning : In my thesis, I have modeled adsorption chromatography and simulated, calibrated, and analyzed models of adsorption chromatography. While my main focus has been modeling and calibration of the models by estimating the parameters, the models used have been partly new. LÄS MER

  5. 4. Aspects of the Design of Preparative Chromatography for Purification of Antibodies

    Författare :David Karlsson; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; ion-exchange chromatography; adsorption kinetics; gels; model calibration; robustness analysis; optimisation; ESPI; diffusion; steric mass action; Langmuir MPM; antibodies; design; Preparative chromatography; modelling; proteins; Chemical technology and engineering;

    Sammanfattning : The development of biotechnological products is becoming more and more expensive. One type of protein attracting a great deal of attention in the biopharmaceutical industry is antibodies, which was used in this work. LÄS MER

  7. 5. Adsorption Isotherm Parameter Estimation in Nonlinear Liquid Chromatography

    Författare :Patrik Forssén; Bertil Gustafsson; Torgny Fornstedt; Georges Guiochon; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; High performance liquid chromatography HPLC ; Preparative chromatography; Competitive adsorption isotherm parameters; Perturbation peak PP method; Inverse method IM ; Computer simulation; Parameter estimation; Numerical method; Scientific Computing; Beräkningsvetenskap;

    Sammanfattning : This thesis concerns the development and validation of methods for the industrially important area of adsorption isotherm parameter estimation in preparative, nonlinear high performance liquid chromatography (HPLC). Preparative chromatography is a powerful separation method to get pure compounds from more or less complex liquid mixtures, e.g. LÄS MER