Sökning: "prefrontal cortex"

Visar resultat 11 - 15 av 131 avhandlingar innehållade orden prefrontal cortex.

1. 11. Inhibition in cognition : neurophysiology and connectivity of gabaergic interneurons in the prefrontal cortex

   Författare :Josina Anna van Lunteren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The prefrontal cortex (PFC) is a cortical region involved in higher-order cognitive functions, it is widely connected to the rest of the neocortex and is involved in tasks that require temporal integration of information. The local PFC circuit contains excitatory pyramidal neurons and inhibitory interneurons, and the interplay between these is essential for computations in the PFC. LÄS MER

3. 12. On the role of parvalbumin interneurons in neuronal network activity in the prefrontal cortex

   Författare :Nicolas Gustavo Guyon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The prefrontal cortex (PFC) is an area important for executive functions, the initiation and temporal organization of goal-directed behavior, as well as social behaviors. Inhibitory interneurons expressing parvalbumin (PV) have a vital role in modulating PFC circuit plasticity and output, as inhibition by PV interneurons on excitatory pyramidal neurons regulates the excitability of the network. LÄS MER

4. 13. Molecular mechanisms underlying increased PDYN and dynorphin expression in the prefrontal cortex of alcoholic men

   Författare :Richard Henriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alcohol dependence is a chronic relapsing disorder caused by drug x gene x environment interactions for which pharmacotherapy is but moderately effective. The prefrontal cortex is a brain region important for cognitive control / behavioral flexibility which function is impaired in alcoholics. LÄS MER

5. 14. On the neuronal basis of cognition : cell-type specific circuitry and functions of the prefrontal cortex

   Författare :Sofie Ährlund-Richter; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis recapitulates the history of research, and current knowledge, of the prefrontal cortex (PFC) in order to provide a context for the included scientific articles. The evident, but ill-defined, symptoms of a perturbation of the PFC is still a conundrum to neuroscientists. LÄS MER

7. 15. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

   Författare :Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. LÄS MER