Sökning: "predictive biomarker"

Visar resultat 21 - 25 av 114 avhandlingar innehållade orden predictive biomarker.

1. 21. Predictive and prognostic biomarkers in oral tongue squamous cell carcinoma

   Författare :Michael Ryott; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Oral tongue squamous cell carcinoma (OTSCC) is an aggressive disease frequently associated with poor prognosis due to the high risk of regional failure and mortality rates have been practically unchanged in Sweden the last fifty years, despite advancements in both diagnostics and treatment. Today we lack means to assess the biological aggressiveness of each individual tumor which varies largely. LÄS MER

3. 22. Multivariate profiling of metabolites in human disease : Method evaluation and application to prostate cancer

   Författare :Elin Thysell; Henrik Antti; Janne Lehtiö; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolite profiling; metabolomics; predictive metabolomics; mass spectrometry; GC-MS; biomarkers; chemometrics; design of experiments; multivariate data analysis; prostate cancer; bone metastases; plasma; biologisk kemi; biological chemistry;

   Sammanfattning : There is an ever increasing need of new technologies for identification of molecular markers for early diagnosis of fatal diseases to allow efficient treatment. In addition, there is great value in finding patterns of metabolites, proteins or genes altered in relation to specific disease conditions to gain a deeper understanding of the underlying mechanisms of disease development. LÄS MER

4. 23. Preventing Cardiovascular Disease. Complementary precision medicine

   Författare :Martiné Wlosinska; Thoraxkirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aged garlic extract; CAC; Placebo-controlled; Double-blinded; Blood pressure; Data science; Predictive models;

   Sammanfattning : AbstractBackground: Non-communicable diseases are the number one killer worldwide and the leading one,cardiovascular disease (CVD), is responsible for more than 30% of all deaths. CVD is a progressive disease whichalso makes it economical, easy and effective to prevent. LÄS MER

5. 24. Emerging biomarkers in cardiometabolic disease

   Författare :John Molvin; Kardiovaskulär forskning - hypertoni; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; type 2; Biomarker discovery; Cardiometabolic disease; cardiometabolic biomarkers; CVD; galectin 4; Olink;

   Sammanfattning : AbstractThe epidemiological association between diabetes and heart failure is well-established and the two entities areemerging as global threats, both individually and synergistically, to an aging population. The exploration of multipleproteins can shed light on pathophysiological pathways in both diabetes and cardiovascular disease. LÄS MER

7. 25. Multiparametric MRI for evaluation of tumour treatment response : Studies of 177Lu-octreotate therapy of neuroendocrine tumour

   Författare :Mikael Montelius; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Functional imaging; IVIM; MRI; DWI; DCE; histology; 177Lu-octreotate; small intestine neuroendocrine tumour; NET; diffusion; perfusion; semi-quantitative; proteomics; ionizing radiation; biology; imaging biomarker;

   Sammanfattning : Clinical assessment of tumour response to treatment largely relies on estimates of tumour size by, e.g., measuring the largest tumour diameters on magnetic resonance (MR) or computed tomography (CT) images, weeks or months after treatment. LÄS MER