Sökning: "predictive biomarker"
Visar resultat 16 - 20 av 114 avhandlingar innehållade orden predictive biomarker.
16. Improving biomarker assessment in breast pathology
Sammanfattning : The accuracy of prognostic and therapy-predictive biomarker assessment in breast tumours is crucial for management and therapy decision in patients with breast cancer. In this thesis, biomarkers used in clinical practice with emphasise on Ki67 and HER2 were studied using several methods including immunocytochemistry, in situ hybridisation, gene expression assays and digital image analysis, with the overall aim to improve routine biomarker evaluation and clarify the prognostic potential in early breast cancer. LÄS MER
17. An integrative strategy for targeted evaluation of biomarker expression in non-small cell lung cancer
Sammanfattning : Despite improvements in therapy, the prognosis for non-small cell lung cancer (NSCLC) patients remains poor, and cure is only possible in localized tumors after surgical resection. A new generation of targeted cancer drugs has led to the expectation that lung cancer therapy can be significantly improved, but these drugs are today only an option in a small subset of NSCLC patients, and their effect is temporary. LÄS MER
18. New predictive and diagnostic biomarkers for preeclampsia
Sammanfattning : Abstract Preeclampsia is a serious pregnancy complication that affects 3-8% of all pregnancies leading to maternal- and fetal morbidity and mortality. The etiology is still not known in detail. Previous findings have shown an up regulation of the genes coding for fetal hemoglobin (HbF) in preeclamptic placentas. LÄS MER
19. The role of RNA-binding motif 3 in epithelial ovarian cancer: A biomarker discovery approach
Sammanfattning : Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). LÄS MER
20. Clinical evaluation and implications of left atrial remodeling in atrial fibrillation : From silent cerebral lesions and atrial stunning to novel electrocardiographic tools for prediction of arrhythmia outcome
Sammanfattning : Atrial fibrillation (AF) is the most common cardiac arrhythmia. Left atrial (LA) remodeling and reverse remodeling are associated with cerebral involvement and cognitive function (CF) changes. Risk stratification for AF related outcomes is essential in the management of patients with AF. LÄS MER