Sökning: "preclinical AD"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden preclinical AD.

  1. 1. Visualising neurodegeneration in the living brain : Preclinical evaluation of PET radioligands

    Författare :Mengfei Xiong; Stina Syvänen; Sahar Roshanbin; Joakim Bergström; Per Borghammer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; Alzheimer s disease; Parkinson s disease; SV2A; neurodegeneration; immunotherapy; transgenic mice; Medicinsk vetenskap; Medical Science; Analytical Chemistry; Analytisk kemi; Pharmacology; Farmakologi; Molekylär medicin; Molecular Medicine;

    Sammanfattning : With an ageing population, the number of people suffering from Alzheimer’s disease (AD) and Parkinson’s disease (PD) escalates yearly. Pathological hallmarks of AD and PD include aggregated proteins and synaptic dysfunction. LÄS MER

  3. 2. Subjective cognitive decline in memory clinic patients - characteristics and clinical relevance : Results from Sahlgrenska University Hospital Memory Clinic in Mölndal

    Författare :Marie Eckerström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cognition; self-assessment; memory; mild cognitive impairment; subjective cognitive decline; dementia; Alzheimer s disease; preclinical AD; stress; depressive symptoms; memory clinic;

    Sammanfattning : Subjective cognitive decline (SCD) refers to concerns – symptoms - regarding one’s cognitive functioning, in the absence of objective evidence of impairment. SCD has been described as a possible stage preceding mild cognitive impairment (MCI) and dementia. LÄS MER

  4. 3. Biomarkers in preclinical familial Alzheimer disease

    Författare :Steinunn Thordardottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Alzheimer disease (AD) is a neurodegenerative disorder, characterized by the accumulation of b-amyloid (Ab) plaques and tangles consisting of hyperphosphorylated tauprotein in the brain. It accounts for 60-70% of dementia cases, making it the most common cause of dementia. LÄS MER

  5. 4. Preclinical PET imaging of Alzheimer's disease progression

    Författare :Xiaotian T. Fang; Stina Syvänen; Dag Sehlin; Lars Lannfelt; Merja Haaparanta-Solin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; transgenic mice; PET; antibody-based tracer; mGluR5; ABP688; di-scFv; amyloid-β;

    Sammanfattning : Amyloid PET imaging with [11C]PIB enabled detection of Aβ for the first time in vivo. However, [11C]PIB is a small molecule that binds only the insoluble Aβ plaque. Rather, the soluble Aβ aggregates are considered the cause of Alzheimer’s disease (AD). LÄS MER

  7. 5. Cancer Immunotherapy : A Preclinical Study of Urinary Bladder Cancer

    Författare :Christina Ninalga; Thomas Tötterman; Magnus Essand; Timothy Ratliff; Uppsala universitet; []
    Nyckelord :Medicine; immunotherapy; bladder carcinoma; cancer; CpG ODNs; Adenoviral vector; CD40L; TRANCE; Lymphotactin; IL2; IL15; Medicin;

    Sammanfattning : Bacillus Calmette Guérin (BCG), or attenuated Mycobacterium bovis, is the gold standard of immunotherapy in the clinic to treat superficial bladder cancer. However, setbacks remain due to a high recurrence rate, side effects, and BCG-refractory disease. LÄS MER