Sökning: "pr medicine"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden pr medicine.

1. 1. Dose Adaptation Based on Pharmacometric Models

   Författare :Johan Wallin; Mats Karlsson; Lena Friberg; Maria Garrido; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Many drugs exhibit major variability in both pharmacokinetic (PK) and pharmacodynamic (PD) parameters that prevents the use of the same dose for all patients. Variability can occur both between patients (IIV) as well as within patients over the course of time (IOV). LÄS MER

3. 2. Development and Evaluation of Nonparametric Mixed Effects Models

   Författare :Paul Baverel; Mats Karlsson; Radojka Savic; Nils Hoem; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonparametric; model; pharmacometrics; pharmacokinetics; pharmacodynamic; imprecision; covariate analysis; parameter distribution; Statistics; computer and systems science; Statistik; data- och systemvetenskap; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biopharmaceutics; Biofarmaci; Clinical Pharmacology; Klinisk farmakologi; Computer Systems; Datorteknik; Farmakologi; Pharmacology; Statistics; Statistik;

   Sammanfattning : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data. The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. LÄS MER

4. 3. Predictive markers for tamoxifen response in primary breast cancer

   Författare :Maria Stendahl; Malmö Patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; General pathology; Cytologi; onkologi; prognosis; Cytology; oncology; cancerology; predictive marker; p27; cyclin D1; tamoxifen; PR; breast cancer; ER; pathological anatomy; Patologi allmän ; patologisk anatomi;

   Sammanfattning : It is well-known that a majority of breast cancers are hormone-dependent, making endocrine therapy an important adjuvant treatment after surgery. Susceptibility to endocrine treatment is determined by the presence of estrogen receptors (ER) and progesterone receptors (PR) in the tumors. LÄS MER

5. 4. Outcomes and Implications of Nasal Measurements in Obstructive Sleep Apnea

   Författare :Hans Christian Hoel; Lund näs- och halssjukdomar Öron-; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstructive sleep apnea OSA ; Respiratory system diagnostic technique; nasal obstruction; Sleep hypopnea; Rhinomanometry;

   Sammanfattning : BackgroundObstructive sleep apnea (OSA) is a prevalent disorder and symptoms of nasal obstruction are highly prevalent in OSA. Treatment of nasal obstruction in OSA patients has shown modest and variable outcomes in reducing the apnea hypopnea index (AHI), but significant improvements in other indicators, such as sleep quality and daytime sleepiness as well as reductions in arousals have been observed. LÄS MER

7. 5. Improving management of STEMI patients treated with primary PCI : Pharmacotherapy, renal function estimation and gender perspective

   Författare :Dimitrios Venetsanos; Eva Swahn; Joakim Alfredsson; Sofia Sederholm-Lawesson; Sigrun Halvorsen; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : This thesis focused on the acute management of patients with ST-segment elevation myocardial infarction (STEMI) in an effort to provide information that may improve outcome. The aim was to evaluate the efficacy and safety of bivalirudin versus unfractionated heparin (UFH) in STEMI patients during primary PCI. LÄS MER