Sökning: "postsynaptic function"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden postsynaptic function.

  1. 1. Implications of localization and transport regulation of postsynaptic membrane proteins for synaptic function and psychiatric disorders

    Författare :Thomas Liebmann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A fundamental means of regulating protein function in cells is through modulation of protein abundance at the sites of action via controlled transport processes. The complexity of neurons makes them especially reliant on regulated delivery of proteins to specialized structures throughout the distant cell branches. LÄS MER

  3. 2. Spatial control of postsynaptic proteins : a role in brain plasticity

    Författare :Markus Kruusmägi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurons communicate via synapses; the strength of each synapse is defined both pre and postsynaptically. Presynaptically, the strength of the synapse is defined by which neurotransmitter is being released and how much. On the postsynaptic membrane a corresponding receptor will receive the transmitter. LÄS MER

  4. 3. Endoplasmic reticulum function in dendrites and dendritic spines of hippocampal neurons

    Författare :Ai Na Ng; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endoplasmic reticulum; primary culture; dendritic spines; live cell imaging; STIM1; carbachol; store-operated calcium entry; 3; familial Alzheimer s disease; 5-dihyroxyphenyglycine;

    Sammanfattning : In the hippocampus, dendritic spines are compartmentalized postsynaptic micro-domains in the excitatory synapse. Subsets of bigger and mushroom-shaped hippocampal dendritic spines contain tubules and cisterns of endoplasmic reticulum (ER) that are connected to the soma and dendrites of the neuron. LÄS MER

  5. 4. SNAP-25 and Cdk5 as exocytotic regulators : consequences for synaptic function and insulin release

    Författare :Jenny Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The process by which cells release substances through fusion of vesicles with the plasma membrane is called exocytosis. Regulated exocytosis needs to be tightly controlled in order to respond to the large variation in stimuli and demands for release of neurotransmitters, peptides and hormones. LÄS MER

  7. 5. Effects of influenza A virus infections and interferon-gamma on synapse formation and function in hippocampal neurons in culture

    Författare :Johan Brask; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Influenza A virus; hippocampal neurons; interferon-gamma; electrophysiology; synapses.;

    Sammanfattning : The central nervous system (CNS) can be the target for several infections that include those with RNA viruses. The parenchyma of the CNS is considered an immuneprivileged site since it is protected behind the blood-brain barrier, expresses no or only low levels of major histocompatibility complex (MHC) molecules and contains a paucity of antigenpresenting cells that prime an immune response. LÄS MER