Sökning: "postmenopausal breast cancer"

Visar resultat 11 - 15 av 48 avhandlingar innehållade orden postmenopausal breast cancer.

  1. 11. Tamoxifen response in primary breast cancer with special reference to tumour-specific VEGF-A and VEGFR2

    Författare :Lisa Rydén; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; prognosis; randomised controlled trial; adjuvant tamoxifen treatment; vascular endothelial growth factor receptor 2; breast cancer; vascular endothelial growth factor A;

    Sammanfattning : Background: Treatment of primary breast cancer is individualised and adjuvant systemic treatment is delivered to most patients after surgery. Oestrogen receptor (ER) status and progesterone receptor status (PR) can define patients who would benefit from adjuvant endocrine therapy with tamoxifen (TAM) alone or as chemo-endocrine therapy. LÄS MER

  3. 12. Alterations in the PI3K/AKT Signaling Pathway and Response to Adjuvant Treatment in Breast Cancer

    Författare :Gizeh Pérez-Tenorio; Olle Stål; Anne Lykkesfeldt; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi;

    Sammanfattning : (PI3K)/AKT signaling pathway could be a cause of therapeutic resistance in breast cancer. The PI3K/AKT pathway controls cell proliferation, cell growth and survival, and its members include oncogenes and tumor suppressor genes. Alterations in this pathway are frequent in cancer. LÄS MER

  4. 13. Aspects of Endocrine Therapy in Primary Breast Cancer. Risk Profiling and Adherence Perspectives for Improving Tailored Adjuvant Treatment

    Författare :Christine Lundgren; LUCC: Lunds universitets cancercentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Abstract: Breast cancers are heterogeneous tumours. Prognostic markers are needed to better profile the patient´s risk, and predictive markers to indicate the expected benefit of systemic treatment. Using gene expression analyses, breast tumours can be divided into intrinsic subtypes. LÄS MER

  5. 14. Diet and postmenopausal breast cancer - With a focus on low-grade inflammation

    Författare :Joana Alves Dias; Nutritionsepidemiologi; []
    Nyckelord :Oxidative stress; low-grade inflammation; Biomarkers of inflammation; cytokines; ICC; variation; diet; dietary recommendations; diet quality index; food patterns; reduced rank regression; obesity; CVD; postmenopausal breast cancer; epidemiology; cross sectional; nested case-control;

    Sammanfattning : Diet-breast cancer studies have shown that “healthy eating patterns” are associated with decreased risk whereas unhealthy patterns (especially those including alcohol) are associated with increased risk, particularly in postmenopausal women. The potential mechanisms behind the observed associations are still under investigation. LÄS MER

  7. 15. Genetic determinants of breast cancer risk

    Författare :Jingmei Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast Neoplasms;

    Sammanfattning : The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches. In an attempt to identify common disease susceptibility alleles for breast cancer, we started off with a hypothesis-free approach, and performed a combined analysis of three genome-wide association studies (GWAS), involving 2,702 women of European ancestry with invasive breast cancer and 5,726 controls. LÄS MER