Sökning: "porphyrin binding studies"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden porphyrin binding studies.

  1. 1. Crystallographic studies on porphyrin metallation by ferrochelatase

    Författare :David Lecerof; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; thermal and mechanical properties; Condensed matter:stucture; fasjämvikt; kristallografi; egenskaper termiska och mekaniska ; Kondenserade materiens egenskaper:struktur; crystallography; phase equilibria; Magnesium; pi-helix; Zinc; ferrochelatase; Metal binding; porphyrin metallation;

    Sammanfattning : Ferrochelatase catalyses the terminal step in heme biosynthesis by inserting a ferrous ion into protoporphyrin IX. The reaction mechanism has in this thesis been studied by mainly crystallographic methods. LÄS MER

  3. 2. Structural and physicochemical studies on metal and porphyrin binding by the Bacillus subtilis ferrochelatase

    Författare :Mattias Hansson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metal specificity; metal binding; porphyrin metallation; time resolved crystallography; fluorescence quenching; X-ray structure; inclusion bodies; Bacillus subtilis; heme biosynthesis; ferrochelatase; hemH;

    Sammanfattning : The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. LÄS MER

  4. 3. Host-Guest Interactions for Structural Analysis of Organic Molecules : Development of new Tools for Stereochemical Characterization

    Författare :Sandra Olsson; Adolf Gogoll; Kari Rissanen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metalloporphyrins; host-guest systems; bis-porphyrin tweezers; stiff stilbene macrocycles; organic synthesis; porphyrin binding studies; NMR; ECCD; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Sammanfattning : The focus of this thesis is on the development of molecular tweezers as host-guest systems for stereochemical characterization of small organic molecules.There are two central problems to stereochemical characterization of small molecules. LÄS MER

  5. 4. Exploring Molecular Interactions : Synthesis and Studies of Clip-Shaped Molecular Hosts

    Författare :Anjaneya Prasad Polavarapu; Helena Grennberg; Adolf Gogoll; Jerker Mårtensson; Uppsala universitet; []
    Nyckelord :Organic chemistry; Glycoluril clips; host-guest systems; supramolecular chemistry; complexation induced shifts; conformational restriction; NMR spectroscopy; fullerene binding; Organisk kemi;

    Sammanfattning : Molecular recognition via noncovalent interactions plays a key role in many biological processes such as antigen-antibody interactions, protein folding, the bonding and catalytic transformation of substrates by enzymes, etc. Amongst these noncovalent interactions, electrostatic interactions, hydrogen bonding, π-π interactions, and metal-to-ligand bonding are the most prominent. LÄS MER

  7. 5. Molecular and morphological studies on non-healing venous leg ulcers

    Författare :Katarina Lundqvist; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; alpha1-microglobulin; heparin binding protein; venous leg ulcers; inflammation; alpha-defensin;

    Sammanfattning : Chronic skin ulcers are a major health problem and an increasing burden on health care providers. These ulcers have various underlying causes, such as venous or arterial insufficiency, diabetes, or vasculitis. Non-healing venous leg ulcers represent a condition characterized by excessive inflammation and presence of bacteria. LÄS MER