Sökning: "population genetics"

Visar resultat 21 - 25 av 469 avhandlingar innehållade orden population genetics.

1. 21. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE

   Författare :Anna-Karin B. Lindqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Systemic lupus erythematosus; complex diseases; genetic susceptibility; linkage analysis; genome scan; candidate gene; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Sammanfattning : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. LÄS MER

3. 22. Familial amyloidosis with polyneuropathy : studies of genetic factors modifying the phenotype of the disease

   Författare :Malin Olsson; Ole B Suhr; Lisbeth Tranebjærg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Familial amyloid polyneuropathy; Amyloidosis; Transthyretin; Allele Frequency; Mitochondria; parent-of-origin; MicroRNA; Single Nucleotide Polymorphism; 3 Untranslated Regions genetics; Medical genetics; Medicinsk genetik; Clinical genetics; Klinisk genetik; genetik; Genetics; klinisk genetik; Clinical Genetics; medicin; Medicine;

   Sammanfattning : Background. Familial Amyloidosis with Polyneuropathy (FAP) is an autosomal dominantly inherited systemic amyloid disease. The disease is caused by mutations in the transthyretin (TTR) gene, where close to 100 different amyloidogenic mutations have been identified. LÄS MER

4. 23. Divergence, admixture and continuity in the human past : Demographic inference using ancient and modern genomes

   Författare :James McKenna; Mattias Jakobsson; Per Sjödin; Ida Moltke; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human evolution; population genetics; ancient genomes; population continuity; divergence; Biology with Specialisation in Human Evolution and Genetics; Biologi med inriktning mot människans evolution och genetik;

   Sammanfattning : Demographic forces shaping the genetic variation we observe today can include population divergences, admixture events and continuity through time. The advancement of high-throughput sequencing technologies, together with developments in molecular and bio-informatics methods, mean the number of ancient genomes available for inference has risen steeply. LÄS MER

5. 24. Neurospora tetrasperma from Natural Populations : Toward the Population Genomics of a Model Fungus

   Författare :Pádraic Corcoran; Hanna Johannesson; Sylvain Glemin; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neurospora; poulation genetics; genomes; introgression; Evolutionary Genetics; Evolutionär genetik;

   Sammanfattning : The study of DNA sequence variation is a powerful approach to study genome evolution, and to reconstruct evolutionary histories of species. In this thesis, I have studied genetic variation in the fungus Neurospora tetrasperma and other closely related Neurospora species. I have focused on N. LÄS MER

7. 25. The Effects of Mutation and Selection on the Rate and Pattern of Molecular Evolution in Birds

   Författare :Sofia Berlin; Hans Ellegren; Adam Eyre-Walker; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; substitution rate; diversity; selection; male mutation bias; birds; Genetik; Genetics; Genetik;

   Sammanfattning : By comparing sequence diversity and divergence on sex chromosomes one can study how the rate of evolution in affected by mutation and/or selection. The rate of mutation in male biased, meaning that relatively more mutations are created in the male germ line than in the female. LÄS MER