Sökning: "polyomavirus persistence"
Hittade 3 avhandlingar innehållade orden polyomavirus persistence.
1. Persistence of polyomavirus : versus immunity to polyoma tumors
Sammanfattning : The aim of this thesis was to understand the role of different specific immune effectors with regard to polyomavirus persistence and polyomavirus induced tumor development. Furthermore, an MHC class I restricted short viral peptide was identified as a target for polyomavirus specific recognition of polyoma tumor cells. LÄS MER
2. Studies on persistent polyomavirus infection in relation to tumor development and options for vaccine and gene therapy
Sammanfattning : Polyomavirus is a small DNA virus capable of inducing tumors in mice with a defective or an immature immune system. The importance of T-cells in prevention of polyoma-induced tumor development has previously been shown. In this thesis, we wished to elucidate the role of humoral immunity with regard to polyomavirus persistence and tumor development. LÄS MER
3. Involvement of T lymphocyte subsets in the rejection of murine tumors by syngeneic or autologous hosts
Sammanfattning : The aim of this thesis is to study the requirement of CD4+ and CD8+ T Iymphocyte subset, CD28 costimulatory molecule and p56kk for the rejection of syngeneic tumor grafts, and the autochthonous tumors induced by Moloney murine sarcoma virus. It also addresses the role of CD4+ and CD8+ T subsets with regard to the polyomavirus persistence and tumor development. LÄS MER