Sökning: "polyamines"

Visar resultat 16 - 20 av 45 avhandlingar innehållade ordet polyamines.

  1. 16. Examining the role of metabolism in Myc-driven tumorigenesis

    Författare :Tacha Zi Plym Forshell; Jonas Nilsson; Mattias Belting; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cancer; Myc; metabolism; polyamines; spermidine synthase; glycolysis; lactate dehydrogenase; serine metabolism; Phgdh; folate metabolism; Shmt; Pim kinase; Pim-3 Kinase; Molecular biology; Molekylärbiologi;

    Sammanfattning : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis.  MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. LÄS MER

  3. 17. Polyamines in foods and human milk

    Författare :Mohamed Atiya Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :putrescine;

    Sammanfattning : Background: Knowing the levels of polyamines, putrescine, spermidine and spermine in foods and human breast milk, and the contribution of daily food choice to polyamine intake and its effect on the levels in breast milk is of interest, due to the association of these bioactive amines to health and disease. There is a lack of relevant information on the content of polyamines in the Swedish Food Database. LÄS MER

  4. 18. Transmethylation, Polyamines and Apoptosis in Amyotrophic Lateral Sclerosis

    Författare :Titti Ekegren; Håkan Askmark; Cecilia Gomes-Trolin; Sten-Magnus Aquilonius; Christopher Fowler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; amyotrophic lateral sclerosis; neurodegeneration; transmethylation; polyamine; apoptosis; Neurovetenskap; Neurology; Neurologi;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive disorder characterized by degeneration of motor neurons in the cortex, brainstem and spinal cord. The patients usually die within 3-5 years after onset. The full etiology of ALS is unknown and many hypotheses have been proposed to explain the neurodegeneration. LÄS MER

  5. 19. Aqueous humor polyamines in the acute phase ocular inflammatory response

    Författare :Kerstin Wickström; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  7. 20. Polyamines are involved in the regulation of S phase and DNA synthesis

    Författare :Kersti Alm; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Djurfysiologi; Animal physiology; cell cycle regulation; p53; DNA strand breaks; replicon organization; topoisomerase II;

    Sammanfattning : Our research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. LÄS MER