Sökning: "poloxamer"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet poloxamer.
1. Controlled release gel formulations and preclinical screening of drug candidates
Sammanfattning : Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. LÄS MER
2. Ternary Block Copolymer - Water - "Oil" Systems: Effects of "Oil" Type and Block Size on Phase Behaviour and Structure
Sammanfattning : It has recently been established in our group that amphiphilic block copolymers consisting of a hydrophilic and a hydrophobic part can self-assemble in the presence of selective solvents (“water” and “oil”) into a variety of different solution and lyotropic liquid crystalline microstructures. The effects of the “oil” type, hydrophilic block size and hydrophobic block type on the phase behavior and microstructure of ternary isothermal copolymer - oil - water systems have been addressed in this thesis. LÄS MER
3. From Fast to Slow Degradation : Different Strategies to Characterise Polymer Degradation by Chromatographic Techniques
Sammanfattning : .... LÄS MER
4. Spray-Dried Powders for Inhalation : Particle Formation and Formulation Concepts
Sammanfattning : Spray drying is a method with a high potential in the preparation of protein particles suitable for pulmonary delivery. However, surface induced denaturation of bio-molecules during atomization and subsequent drying can be substantial and it is therefore important to develop new formulation concept for concurrent encapsulation and stabilization of proteins during spray drying. LÄS MER
5. Preparation and characterisation of biodegradable microspheres for the delivery of bioactive compounds
Sammanfattning : The incorporation of bioactive compounds into biodegradable polymer microspheres has several advantages. Firstly, the drug substance is protected from physiological degradation. Secondly, using microspheres from polymers with different degradation mechanisms, it is possible to design different release profiles with desired release rates. LÄS MER