Sökning: "podocytes"

Visar resultat 6 - 10 av 34 avhandlingar innehållade ordet podocytes.

  1. 6. Nephrin : intracellular trafficking and podocyte maturation

    Författare :Stefania Cotta Doné; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nephrin; CNF; podocytes; glomerulus;

    Sammanfattning : Congenital nephrotic syndrome of the Finnish type, CNF, is an autossomal recessive disorder caused by mutations in the NPHS1 gene and, consequently, in its product nephrin, a 180 kDa transmembrane protein belonging to the immunoglobulin superfamily of adhesion molecules. In kidneys, nephrin is located exclusively to the podocyte slit diaphragm and it has a key role in organising amd maintaining the renal ultrafiltation barrier. LÄS MER

  3. 7. Nephrin-mutations in congenital nephrotic syndrome of the Finnish type and cell lineage specific gene regulation

    Författare :Olga Beltcheva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nephrin; NPHS 1; CNF; podocytes; promoter;

    Sammanfattning : Kidneys, the main excretory organs in vertebrates, play central role in removing water soluble metabolic waste products from the organism. Many acquired and inherited renal diseases in man lead to kidney dysfunction and nephrotic syndrome - life-threatening condition affecting increasing number of people in the modem society. LÄS MER

  4. 8. Characterization of novel podocyte proteins in the glomerular filtration barrier

    Författare :Laleh Sistani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The kidney is considered the most important organ of excretion eliminating the body from metabolic waste products. The nephron is the functional unit of the kidney, composed of a cluster of capillaries named glomerulus, and a tubular system. The blood is filtered in the glomerular capillaries across the glomerular filtration barrier. LÄS MER

  5. 9. Putting the pieces together : elucidation of podocyte biology in the homeostasis of the kidney filtration barrier

    Författare :Patricia M Rodriguez Rivera; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : End-stage renal disease (ESRD) is a devastating condition that can only be treated with chronic dialysis or kidney transplantation. ESRD treatment costs account for up to 10% of healthcare budgets in the Western world. The 5-year survival for patients in dialysis is only about 40%. Glomerular disease processes are the main cause of ESRD. LÄS MER

  7. 10. A Podocyte view on RhoGTPases and actin cytoskeleton regulation

    Författare :Lovisa Bergwall; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Podocyte; RhoGTPases; Actin cytoskeleton regulation;

    Sammanfattning : Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice. LÄS MER