Sökning: "podocytes"

Visar resultat 11 - 15 av 34 avhandlingar innehållade ordet podocytes.

1. 11. Identification and characterization of kidney glomerulus-associated genes and proteins

   Författare :Ljubica Perisic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The kidney glomerulus is a micro-organ comprised of a molecular filtration barrier that prevents the loss of blood proteins into the primary filtrate. This function is dependent on the coordination of its three constituent layers: the endothelium, the glomerular basement membrane and the podocytes. LÄS MER

3. 12. The expression of the structural proteins dendrin, Plekhh2 and Neph1 in the glomerular filtration barrier

   Författare :Jenny Hulkko; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: The podocytes are injured in many acquired glomerular diseases. This may present as proteinuria or morphological changes such as foot process effacement (FPE) or loss of podocytes in the urine. The exact mechanisms are still mainly unknown. LÄS MER

4. 13. Characterization of novel glomerular proteins : role in physiology and disease

   Författare :Ann-Charlotte Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy. The costs for treatment of CKD represent an enormous burden to the health care system. LÄS MER

5. 14. Functional and molecular aspects of the glomerular barrier

   Författare :Anna Björnson Granqvist; Göteborgs universitet; []
   Nyckelord :glomerular endothelium; glycocalyx; podocyte; proteoglycan; glycosaminoglycans; nephrotic syndrome;

   Sammanfattning : The kidneys are crucial for maintaining a normal salt-water balance in the body, which is a prerequisite for life. They do that by filtering 180 liters of plasma per day across the highly permselective glomerular barrier and reabsorbing 99 % of the filtrate. LÄS MER

7. 15. The expression of the structural proteins dendrin and Neph1 in the glomerular filtration barrier in proteinuria

   Författare :Jenny Hulkko; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: In the normal kidney, the glomerular filtration barrier successfully clears about one litre blood per minute. Damage to the filtration barrier might lead to protein leakage in the urine – proteinuria. The major ultra-structural finding in glomerular diseases with proteinuria is foot process effacement (FPE). LÄS MER