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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria

    Författare :Anna Martner; Göteborgs universitet; []
    Nyckelord :Gram-positive; Gram-negative bacteria; Streptococcus pneumoniae; IL-12; autolysin; pneumolysin; CD4 T cells; monocytes macrophages; dendritic cells;

    Sammanfattning : Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria stimulate monocytes to produce large amounts of IL-12. LÄS MER

  3. 2. Streptococcus pneumoniae and the host : activation, evasion and modulation of the human innate immune system

    Författare :Laura Spelmink; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae is a major cause of severe infections such as pneumonia, septicemia and meningitis, but also a common colonizer of the nasopharynx in children. In most individuals colonization is harmless and eventually cleared by the immune system, but in rare cases pneumococci can reach deeper into the body and cause diseases. LÄS MER

  4. 3. Linking innate and adaptive immunity to streptococcus pneumoniae

    Författare :Marie Olliver; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae (the pneumococcus) most commonly colonizes the human nasopharyngeal mucosa without causing any symptoms. However, this organism has the potential to spread to normally sterile sites and cause pneumonia, meningitis or sepsis; diseases which are characterized by excessive inflammation. LÄS MER

  5. 4. Streptococcus pneumoniae : epidemiological, clinical and serological studies

    Författare :Lars Å. Burman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pneumoniae; incidence; predisposing factors; prognosis; serotyping; etiology of pneumonia; diagnostic methods; COA; CIE; pneumococcal serology;

    Sammanfattning : A retrospective study of invasive pneumococcal disease in patients from Greater Göteborg in 1964- 1980 identified 125 cases of meningitis, 305 of pneumonia, 61 of septicemia with unknown focus, and 17 with other manifestations, all verified by cultures from normally sterile body fluids. The incidence was several times higher in infants and in the elderly than in any other age-group. LÄS MER

  7. 5. Mechanisms for pneumococcal meningitis and a new vaccine platform to raise a serotype-independent protection in the host

    Författare :Sigrun Thorsdottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae is a highly relevant pathogenic bacterium, responsible for a large fraction of deaths and disease morbidity in the world. The pneumococcus remains the leading cause of life-threatening pneumonia, septicemia and meningitis beyond neonatal age, despite global implementation of vaccination programs. LÄS MER