Sökning: "ploidy levels"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden ploidy levels.

  1. 1. Ecology and evolution of tolerance in two cruciferous species

    Författare :Elin Boalt; Kari Lehtilä; Johan Ehrlén; Julia Koricheva; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; herbivory; tolerance; methodology; Raphanus raphanistrum; Cardamine pratensis; folivory; apex removal; plant competition; ploidy levels; herbivore pressure; Other biology; Övrig biologi; växtekologi; Plant Ecology;

    Sammanfattning : Tolerance to herbivory is the ability of plants to maintain fitness in spite of damage. The goal of this thesis is to investigate the genetic variation and expression of tolerance within species, determine whether and in what conditions tolerance has negative side-effects, and how tolerance is affected by different ecological factors. LÄS MER

  3. 2. Protein expression in prostate cancer

    Författare :Helena Lexander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Two-dimensional gel electrophoresis; protein expression; biomarker; Gleason grade; DNA-ploidy;

    Sammanfattning : The molecular pathology of prostate cancer (PCa) is complex and the pathways and the acquired molecular defects responsible for PCa initiation, development and progression are still largely unknown. Tumors of the prostate have an unpredictable behavior and in clinically detected cancers it is presently not possible to assess tumor aggressiveness. LÄS MER

  4. 3. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

    Författare :Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

    Sammanfattning : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. LÄS MER

  5. 4. Clinical fluorescence cytometry : improvements to preparation methods and instrumentation

    Författare :Thomas Heiden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fluorescence analysis; flow cytometry; image cytometry; DNA ploidy; proliferation; apoptosis; paraffin-embedded tissues; fresh tissues; S-phase fraction; debris; aggregates; spectral overlap; wavelength switching;

    Sammanfattning : Fluorescence cytometry, which can be carried out by flow or image cytometry (FCM, ICM), provides a highly sensitive and specific tool for quantitative analysis of cell material. It is emerging from being a pure research method and becoming an important adjunct to clinical practice. To better realize its potential, more research is needed. LÄS MER

  7. 5. Neoadjuvant hormone treatment in localized prostate cancer : a clinical and histopathological study

    Författare :Magnus Hellström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Localized prostate cancer; radical prostatectomy; neo-adjuvant androgen deprivation; GnRH-agonist; histopathology; immunohistochemistry; image analysis; cancer volume; DNA ploidy patterns; PSA in serum; follow-up; prognosisStockholm 1996;

    Sammanfattning : Surgical treatment of localized prostate cancer may be hampered by the spread of cancer through the prostate capsule and in the surgical margins. The prostate is dependent on androgen hormones for its growth and function. LÄS MER