Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

   Författare :Fredrik Persson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

   Sammanfattning : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. LÄS MER

3. 2. Studies of PLAG1 and HMGIC fusion oncogenes in human tumors

   Författare :Anna-Karin Ström; Göteborgs universitet; []
   Nyckelord :Pleomorphic adenoma; carcinoma ex pleomorphic adenoma; lipoblastoma; PLAG1; HMGIC; chromosome translocation; promoter swapping; fusion oncogene; gene amplification;

   Sammanfattning : .... LÄS MER

4. 3. Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors

   Författare :Maryam K. Afshari; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fusion oncogene; MYB; NFIB; PLAG1; HMGA2; adenoid cystic carcinoma; pleomorphic adenoma; targeted therapy;

   Sammanfattning : Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many solid tumors, including salivary gland tumors (SGTs). LÄS MER