Sökning: "platelet-derived growth factor-B"

Visar resultat 11 - 15 av 21 avhandlingar innehållade orden platelet-derived growth factor-B.

  1. 11. Gene expression and its physiological control in disease and development : Studies on the human PDGF-B gene and tumour hypoxia

    Författare :Erik Ullerås; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Zoologisk utvecklingsbiologi; Animal Development;

    Sammanfattning : Strict control of gene expression is essential during development and in response to physiological stimuli. This thesis describes the functional characterisation of the gene regulatory mechanisms controlling the expression of the potent human growth factor Platelet Derived Growth Factor B gene, in a cell type specific context and in response to low oxygen tension. LÄS MER

  3. 12. Effects of PDGF-B gene inactivation in endothelial cell

    Författare :Mattias Bjarnegård; Göteborgs universitet; []
    Nyckelord :gene targeting; Cre loxP; PDGF; pericyte; mouse; microangiopathy;

    Sammanfattning : Platelet-derived growth factor-B (PDGF-B) is expressed by endothelial cells, neurons, macrophages and platelets. The relative importance of these cellular PDGF-B sources in vivo has been addressed by the creation of a conditional PDGF-B allele, which in the presence of a specific recombinase can be silenced in different tissues. LÄS MER

  4. 13. Organ-specific mechanisms of vascular development in the mesentery

    Författare :Yang Zhang; Taija Mäkinen; Wiebke Herzog; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphatic vasculature; mesentery; hemogenic endothelium; lymphvasculogenesis; endothelial integrity; platelet; blood-filled lymphatic vessel; morphogenesis and maturation; compensation;

    Sammanfattning : Understanding how the vascular systems are formed has significant clinical importance. General mechanisms underlying vascular development have been extensively studied during the past decades. However, the mechanisms regulating the development and function of the blood and lymphatic vessels in specific organs are poorly understood. LÄS MER

  5. 14. Cardiovascular role of PDGF-B in development and disease. Studies in genetically engineered mice

    Författare :Henrik Nyström; Göteborgs universitet; []
    Nyckelord :atherosclerosis; cardiovascular disease; cell retention; in vivo physiology; neointimal hyperplasia; PDGF; transgenic mice; vascular function; vascular smooth muscle cell;

    Sammanfattning : Platelet-derived growth factor B (PDGF-B) is vital for microvascular development, and retention of PDGF-B to extracellular matrix (ECM) is important in this process. However, the role and source of PDGF-B in development of macrovascular function is disputed. LÄS MER

  7. 15. Photoreceptor degeneration, second order neuron remodeling and glia reactivity in an in vivo and in vitro model of retinal neurodegeneration

    Författare :Tanzina Mollick; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicin; Biomedicine;

    Sammanfattning : Photoreceptors have the ability to last during the entire lifespan of an individual. Being the first line of neurons in the visual transduction pathway, their health and maintenance is eminent for proper retinal function. However, photoreceptors are susceptible to neurodegenerative retinal dystrophies. LÄS MER