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Visar resultat 1 - 5 av 24 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Tissue Factor Biological Functions : Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

   Författare :Mikael Åberg; Agneta Siegbahn; Carl-Henrik Heldin; Teet Velling; Björn Dahlbäck; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; Clinical chemistry; Klinisk kemi;

   Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. LÄS MER

3. 2. Crosstalk Between Activated Platelets and the Complement System

   Författare :Osama A. Hamad; Bo Nilsson; Kristina Ekdahl-Nilsson; Lennart Truedsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; activated platelets; TRAP; chondroitin sulfate; C1q; factor H; C4BP; C3; Compstatin; complement; platelet-leukocyte complexes; platelet microparticles; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. LÄS MER

4. 3. On the role of neutrophils and NETosis in acute pancreatitis. De neutrophilis NETosique ad pancreatitim acutam pertinentibus

   Författare :Johan Linders; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute pancreatitis; neutrophil; Neutrophil extracellular traps NETs ; Platelets; CXCL 4; microparticles; IP6K1; platelet-neutrophil complexes; eCIRP; Complement C3;

   Sammanfattning : .... LÄS MER

5. 4. Vitamin K-dependent protein S - studies of synthesis, structure and function

   Författare :Sofia Somajo; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; coagulation; microparticles; protein C; protein S; structure; tissue factor pathway inhibitor;

   Sammanfattning : This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. LÄS MER

7. 5. Clinical, epidemiological and molecular aspects of hemolytic uremic syndrome

   Författare :Lisa Sartz; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; O157; C3; microparticles; Shiga toxin; epidemiology; EHEC; hemolytic uremic syndrome; complement; tissue factor; atypical HUS;

   Sammanfattning : Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children in the western world. HUS is characterized by the triad of hemolytic anemia, thrombocytopenia and renal failure. There are two main subtypes of HUS; typical or D+ (D stands for diarrhea) HUS associated with enterohemorrhagic E. LÄS MER