Sökning: "plasma protein s a"

Visar resultat 1 - 5 av 182 avhandlingar innehållade orden plasma protein s a.

1. 1. Vitamin K-dependent protein S - studies of synthesis, structure and function

   Författare :Sofia Somajo; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; coagulation; microparticles; protein C; protein S; structure; tissue factor pathway inhibitor;

   Sammanfattning : This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. LÄS MER

3. 2. Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S

   Författare :Petra Evenäs; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; tyrosine phosphorylation.; Sky receptor; SHBG-like region; protein S; G domain; Gas6; Activated protein C; C4b-binding protein; Proteins; enzymology; Proteiner; enzymologi;

   Sammanfattning : The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. LÄS MER

4. 3. C4b-binding protein: Identification of binding sites and a possible function of the interaction with protein S

   Författare :Joanna Webb; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; apoptosis; binding sites; complement; C4b-binding protein; protein S; Klinisk kemi;

   Sammanfattning : The subject of this thesis is plasma protein C4b-binding protein (C4BP). C4BP is an important regulator of the classical pathway of the complement system, a cascade-like system comprised of over 35 proteins, which partakes in the defence against micro-organisms and is involved of clearance of immune-complexes and apoptotic cells. LÄS MER

5. 4. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease

   Författare :Annika Olsson; Göteborgs universitet; []
   Nyckelord :Alzheimer s disease; amyloid precursor protein; ß-amyloid; biomarker; cerebrospinal fluid; enzyme-linked immunosorbent assay; plasma;

   Sammanfattning : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). LÄS MER

7. 5. Pharmacokinetics of 2-mercaptopropionylglycine (Tiopronin) in man

   Författare :Margaretha S. Carlsson; Per Sjöström; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : 2-Mercaptopropionylglycine (2-MPG, tiopronin) has been used successfully in the treatment of cystinuria despite the lack of knowledge of its pharmacokinetics. Therefore methods based on high-performance liquid chromatography and fluorometric detection were developed for quantitative analysis. LÄS MER