Sökning: "plasma lipid"

Visar resultat 1 - 5 av 308 avhandlingar innehållade orden plasma lipid.

  1. 1. Cholesterol in T cells : homeostasis, plasma membrane organization and signaling

    Författare :Saleemulla Mahammad; Ingela Parmryd; Thomas Harder; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plasma membrane; T cells; Cholesterol; Lipid rafts; Membrane organization; Cholesterol homeostasis; cholesteryl esters; Cell biology; Cellbiologi; Cell Biology; cellbiologi;

    Sammanfattning : The plasma membrane of eukaryotic cells contains cholesterol and glycosphingolipids enriched nanodomains known as lipid rafts; which are believed to exist in a liquid ordered (lo) state. Methyl-beta-cyclodextrin (MBCD) is used to deplete cellular cholesterol and a widespread assumption is that MBCD preferentially targets cholesterol in lipid rafts. LÄS MER

  3. 2. Lipid peroxidation in vivo : Evaluation and application of methods for measurement

    Författare :Eva Södergren; Uppsala universitet; []
    Nyckelord :Medical sciences; lipid peroxidation; hydroperoxides; F2-isoprostanes; MDA; prostaglandins; measurement; carbon tetrachloride; vitamin E; dietary fat quality; rapeseed oil; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Geriatrics; geriatrik;

    Sammanfattning : Lipid peroxidation is thought to be an important factor in the pathophysiology of a number of diseases and in the process of ageing, but its measurement in vivo has been difficult. The aim of this thesis was to evaluate methods for measurement of lipid peroxidation in vivo that are suitable for clinical investigations, and to apply these methods in animal and human studies investigating basal conditions and situations associated with increased lipid peroxidation. LÄS MER

  4. 3. The assembly of cytosolic lipid droplets and its effect on insulin sensitivity

    Författare :Pontus Boström; Göteborgs universitet; []
    Nyckelord :diabetes; lipid metabolism; insulin resistance; lipid droplets; ADFP; SNARE;

    Sammanfattning : Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation of triglycerides occurs in so-called lipid droplets in the cytosol. LÄS MER

  5. 4. Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models

    Författare :Maria Skoog; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Lipid; ACTH; Apolipoprotein-B; Cholesterol; Human; Rat; Rabbit; Medicin människa och djur ;

    Sammanfattning : Abstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. LÄS MER

  7. 5. In Vitro – In Vivo Correlation of Injectable Lipid Formulations

    Författare :Lars Söderberg; Livsmedelsteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; EC 50; erythrocyte; human plasma; lipid injectable formulation; IVIVC; fatty acid; in vitro release; Peripheral nerve block; neurolytic; structure-activity;

    Sammanfattning : In order to develop new pharmaceuticals, to optimize pharmacotherapy and secure patient safety, documentation of the properties of pharmaceutical formulations is a most important process. A significant practical problem associated with pre-clinical evaluation of lipophilic substances with pharmacological properties is their low aqueous solubility. LÄS MER