Sökning: "plasma clearance"

Visar resultat 21 - 25 av 154 avhandlingar innehållade orden plasma clearance.

1. 21. Volume kinetics of glucose solutions given by intravenous infusion

   Författare :Fredrik Sjöstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Volume kinetics; osmosis; dehydration; rehydration; glucose solutions; glucose; hypovolemia; hypoglycemia; fluids; intravenous fluid therapy; fluid shifts; plasma volume; dilution; plasma dilution; intracellular hydration; central volume.;

   Sammanfattning : Fluid therapy is often cumbersome to plan since the distribution and the elimination of the administered solution are difficult to analyze in the clinical setting. The knowledge of the adequate rate and dose for each individual patient and under various physiological conditions would be very attractive to obtain in order to avoid fluid overload and hyperglycemia. LÄS MER

3. 22. Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients

   Författare :Karin Lindahl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatits C; ribavirin; pharmacokinetics; renal function; plasma concentration; anaemia; population pharmacokinetic analysis; peginterferon; sustained viral response;

   Sammanfattning : Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available are not optimal either regarding cure of disease or risk of side effects. LÄS MER

4. 23. Familial hypercholesterolemia in Sweden : genetic and metabolic studies

   Författare :Suzanne Lind; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Familial hypercholesterolemia; LDL receptor gene mutations; LDL cholesterol; bile acids; autosomal recessive hypercholesterolemia; growth hormone; LDL clearance.;

   Sammanfattning : Familial hypercholesterolemia (FH) is inherited as an autosomal codominant disease, usually caused by mutations in the LDL receptor (LDLR) gene. Heterozygous FH is a common disease with a prevalence of about 1/500 in most populations. Clinically, FH is characterized by elevated LDL cholesterol, tendon xanthomas and premature atherosclerosis. LÄS MER

5. 24. Effects of surgery on substrate metabolism in human adipose tissue

   Författare :Göran Felländer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :trauma; insulin resistance; free fatty acids; lactate; pyruvate; glucose; microdialysis; fat cells; catecholamines; cholecystectomy; anesthesia; 133Xe clearance; adipose tissue blood flow; vasodilation.;

   Sammanfattning : The aim of this study was to characterize the effects of cholecystectomy on substrate metabolism in vivo and blood flow in adipose tissue using microdialysis of the tissue interstitial compartment. One day after surgery, general insulin resistance and glucose intolerance developed, there was no involvement of the glucose metabolism in adipose tissue. LÄS MER

7. 25. Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment

   Författare :Annette Bruchfeld; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatitis C; kidney transplantation; patient and graft survival; renal replacement therapy; dialysis; renal insufficiency; interferon-alpha; ribavirin; plasma concentration; anaemia; population pharmacokinetics; renal function.;

   Sammanfattning : Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. LÄS MER