Sökning: "placebo."

Visar resultat 1 - 5 av 442 avhandlingar innehållade ordet placebo..

  1. 1. Pharmacological therapy in obstructive sleep apnea - Methodology and interventional aspects of carbonic anhydrase modulation

    Författare :Erik Hoff; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; obstructive sleep apnea; carbonic anhydrase; endotype; drug therapy; hypoxia; hypoxia-inducible factor 1α; placebo;

    Sammanfattning : BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent disease with potential severe short- and long-term consequences such as daytime sleepiness and cardiovascular disease. Recurrent total or partial collapse of the upper airway during sleep leads to sleep fragmentation and intermittent hypoxia/hypercapnia. LÄS MER

  3. 2. Bending and Mending the Neurosignature : Elicting the Relaxation Response with help of Flotation-REST ( Restricted Environmental Stimulation Technique) in Patients with Stress Related Pain

    Författare :Sven-Åke Bood; Torsten Norlander; Gun Nordström; Lars-Gösta Dahlöf; Karlstads universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Burn-out; flotation-REST; pain; prolactin; relaxation response; stress; attention; depression; placebo.; Psychology; Psykologi; Psykologi; Psychology;

    Sammanfattning : Abstract. The overarching purpose of the current thesis was to assess the long term effects of a documented treatment program involving flotation-REST for the experience of pain, from the point of view of variables connected with Melzack´s neuromatrix theory, and to examine the extent of a potential attention-placebo effect in connection with flotation-REST. LÄS MER

  4. 3. Imaging serotonin and dopamine transporters in social anxiety disorder : Characterization, treatment and expectancy effects

    Författare :Olof Hjorth; Tomas Furmark; Andreas Frick; Eduard Maron; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; PET; serotonin; dopamine; placebo; SSRI; CBT; MRI; Psychology; Psykologi; Psychiatry; Psykiatri; Radiology; Radiologi;

    Sammanfattning : The monoamines serotonin and dopamine are likely to be involved in the pathophysiology of social anxiety and other affective disorders, but their respective contributions and putative interactions in the causes and cures of these disorders are still not well understood. It is also largely unknown if and how expectations of treatment success affect brain neurochemistry and neural activations, and if expectations interact with antidepressants like selective serotonin reuptake inhibitors (SSRIs). LÄS MER

  5. 4. Ovarian Steroid Hormones, Emotion Processing and Mood

    Författare :Malin Gingnell; Inger Sundström-Poromaa; Mats Fredrikson; Johan Wikström; Larry Cahill; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; premenstrual dysphoric disorder; menstrual cycle; combined oral contraceptives; estrogen; estradiol; progesterone; ethinyl-estradiol; levonorgestrel; randomized clinical trial; placebo; fMRI; amygdala; ACC; insula; dlPFC; mPFC; IFG; MFG; Medicinsk vetenskap; Medical Science; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : It is known that some psychiatric disorders may deteriorate in relation to the menstrual cycle. However, in some conditions, such as premenstrual dysphoric disorder (PMDD), symptomatology is triggered mainly by the variations in ovarian steroid hormones. LÄS MER

  7. 5. Methods for handling model misspecification in pharmacometric model-based approaches for the analysis of longitudinal clinical trial data

    Författare :Estelle Chasseloup; Mats Karlsson; Andrew Hooker; Karl Brendel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; misspecification; type I error; power; accuracy; placebo; individual model averaging; IMA; likelihood ratio test; LRT; model averaging; covariate selection; mixture models; visual predictive checks; VPC; avatars; digital twins; virtual individual; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Pharmacometrics model-based analyses proved to be increasingly useful in drug discovery and development. This usefulness was made evident by the formalisation of the model-integrated drug discovery and development framework (MID3). LÄS MER