Sökning: "physical diseases"
Visar resultat 1 - 5 av 377 avhandlingar innehållade orden physical diseases.
1. Modeling DNA Damage
Sammanfattning : In this thesis methods of computational chemistry have been used to examine DNA damaging processes initiated by ionizing radiation, free radicals, or Low-Energy Electrons (LEE). The computational chemistry method based on quantum mechanics that has been mainly used here is the Density Functional Theory (DFT). LÄS MER
2. Modeling of biomembranes: from computational toxicology to simulations of neurodegenerative diseases
Sammanfattning : It was known from the middle of the last century that a cell-membrane is a lipid bilayer. Since that time a large number of experimental studies has been done in order to see how a certain molecule can penetrate through a membrane. LÄS MER
3. Bone mass and physical activity
Sammanfattning : Abstract Weak and osteoporotic bones in old age are an increasing cause of mortality and painful physical impairment of the elderly, especially in the western world. Bone mineral accrual during childhood and adolescence is thought to play a vital role in preventing osteoporosis. LÄS MER
4. Biological membrane interfaces involved in diseases : a biophysical study
Sammanfattning : Interactions between peptides and biological lipid membranes play a crucial role in many cellular processes such as in the mechanism behind Alzheimer’s disease where amyloid-beta peptide (Abeta)is thought to be a key component. The initial step of binding between a surface active peptide and its target membrane or membrane receptor can involve a non specific electrostatic association where positively charged amino acid residues and a negatively charged membrane surface interact. LÄS MER
5. FACING THE CHALLENGE OF SKIN PENETRATION - A STUDY ON LIPIDIC LIQUID CRYSTALLINE PHASES FOR DERMAL DRUG DELIVERY
Sammanfattning : The skin is a barrier which protects us against daily attacks of foreign substances. From a pharmaceutical perspective it is also an interesting delivery route with its large surface and possibility to reach the blood stream circumventing first passage metabolism. With the varied size, structure etc. LÄS MER