Sökning: "phylogenetic clustering"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden phylogenetic clustering.

  1. 1. Computational Problems in Modeling Evolution and Inferring Gene Families

    Författare :Mehmood Alam Khan; Lars Arvestad; Jens Lagergren; Christophe Dessimoz; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; Phylogenetics; Lateral Gene Transfer; Gene Families; Clustering; Datalogi; Computer Science;

    Sammanfattning : Over the last few decades, phylogenetics has emerged as a very promising field, facilitating a comparative framework to explain the genetic relationships among all the living organisms on earth. These genetic relationships are typically represented by a bifurcating phylogenetic tree — the tree of life. LÄS MER

  3. 2. Atypical Solute Carriers : Identification, evolutionary conservation, structure and histology of novel membrane-bound transporters

    Författare :Emelie Perland; Robert Fredriksson; Helgi Schiöth; Åsa Mackenzie; Sonchita Bagchi; Carsten Uhd Nielsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Major facilitator superfamily; solute carrier; transporter; protein expression; mRNA expression; phylogenetic clustering; orthologues; co-expression; subcellular location; nutrition.; Neuroscience; Neurovetenskap;

    Sammanfattning : Solute carriers (SLCs) constitute the largest family of membrane-bound transporter proteins in humans, and they convey transport of nutrients, ions, drugs and waste over cellular membranes via facilitative diffusion, co-transport or exchange. Several SLCs are associated with diseases and their location in membranes and specific substrate transport makes them excellent as drug targets. LÄS MER

  4. 3. Reticulate Evolution in Diphasiastrum (Lycopodiaceae)

    Författare :Sunniva Margrethe Due Aagaard; Niklas Wikström; Tom A. Ranker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; admixture analysis; Bayesian clustering; Diphasiastrum; Feulgen DNA image densitometry; homoploid hybridization; Lycopodiaceae; phylogenetic analysis; polyploidy; reticulate evolution; Systematics and phylogenetics; Systematik och fylogeni; systematisk botanik; Systematic Botany;

    Sammanfattning : In this thesis relationships and the occurrence of reticulate evolutionary events in the club moss genus Diphasiastrum are investigated. Diphasiastrum is initially established as a monophyletic group within Lycopodiaceae using non recombinant chloroplast sequence data. LÄS MER

  5. 4. Development of New Methods for Inferring and Evaluating Phylogenetic Trees

    Författare :Tobias Hill; Helgi Schiöth; Robert Fredriksson; Mark Wilkinson; Uppsala universitet; []
    Nyckelord :Pharmacology; Evolution; Phylogeny; SPR; Genetic Algorithm; Tree metrics; Farmakologi;

    Sammanfattning : Inferring phylogeny is a difficult computational problem. Heuristics are necessary to minimize the time spent evaluating non optimal trees. In paper I, we developed an approach for heuristic searching, using a genetic algorithm. Genetic algorithms mimic the natural selections ability to solve complex problems. LÄS MER

  7. 5. Ecological and evolutionary assembly processes and metacommunity structure

    Författare :Mikael Pontarp; Evolutionär ekologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Community; metacommunity; phylogenetic signal; ecology; evolution; assembly process; marine bacteria; habitat filtering; competition; mathematical modeling; simulation; eco-evolutionary;

    Sammanfattning : This thesis aims to elucidate the link between abiotic and biotic effects and biogeographical contingencies, eco-evolutionary assembly processes, and community structure in a spatially explicit metacommunity framework. To this end, we used structure analysis of naturally sampled and experimentally manipulated marine bacterial communities and mathematical eco-evolutionary modeling and simulations of metacommunity assembly. LÄS MER