Sökning: "phosphonothioate"

Hittade 5 avhandlingar innehållade ordet phosphonothioate.

  1. 1. Expanding the H-phosphonate and H-phosphonothioate chemistry towards biologically important phosphate analogs

    Författare :Gaston Lavén; Jacek Stawinski; Wojciech T. Markiewicz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phosphonate; phosphonothioate; H-phosphonate; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis focuses on chemical transformations of H-phosphonate and H-phosphonothioate and can be divided in two parts. The first part, is devoted to the development of the palladium-catalyzed P-C bond formation. Both mechanistic and synthetic studies of the transformations have been performed. LÄS MER

  3. 2. Studies on Oxidative Couplings in H-Phosphonate Chemistry

    Författare :Johan Nilsson; Jacek Stawinski; Esther Kuyl-Yeheskiely; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; oxidative coupling; H-phosphonate; H-phosphonothioate; organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : In this thesis oxidative coupling of H-phosphonate and H phosphonothioate diesters with different alcohols and amines are presented. Since the reactions with alcohols previously have been particularly unfavourable due to competing side reactions, a modified protocol leading to high coupling yields of structurally diverse hydroxylic components was developed. LÄS MER

  4. 3. Nucleoside H-phosphonates and H-phosphonothioates : some chemical and stereochemical studies

    Författare :Mats Thelin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Phosphonic acid's reaction towards sterically hindered acyl chlorides has been investigated. A new synthetic method for the synthesis of nucleoside Hphosphonate monoesters has been developed. Furthermore, a method for the synthesis of nucleoside H-phosphonothioate monoesters has also been developed. LÄS MER

  5. 4. Studies on the synthesis of nucleotide analogues containing P-F and P-Se bonds

    Författare :Martin Bollmark; Janusz Rachon; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : In the present work, new synthetic approaches to the synthesis of nucleoside phosphorofluoridate and phosphorofluoridothioate diesters have been developed. These procedures involve either oxidative transformation of the corresponding H-phosphonate or H-phosphonothioate diesters in the presence of fluoride anion or iodine-promoted desulfurization of phosphorothioate or phosphorodithioate diesters in the presence of fluoride anion. LÄS MER

  7. 5. Studies on Transformations of H-Phosphonates into DNA Analogues Containing P-S or P-C Bonds

    Författare :Tommy Johansson; Jacek Stawinski; Joachim Wolfgang Engels; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : In this thesis, mechanistic and synthetic studies on transformations of H-phosphonates into DNA analogues containing P-S or P-C bonds are described. Configurational stability of dinucleoside H-phosphonates and the stereochemical course of their sulfurisation in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were investigated. LÄS MER