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Visar resultat 1 - 5 av 12 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Phosphoinositides control insulin secretion through multiple routes

    Författare :Phuoc My Nguyen; Christina Bark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phosphoinositides; PI 4 P; PI 4; 5 P2; Ca2 ; optogenetics; VDCC; Sac2; OSBP; OSW-1; cholesterol; membrane contact sites;

    Sammanfattning : Glucose-stimulated insulin secretion from pancreatic beta cells is the sequence of events that starts with glucose uptake and ends with the fusion of insulin granules with the plasma membrane through Ca2+-triggered exocytosis. Phosphoinositides are minor components of all cellular membranes, yet play fundamental roles as regulators of many cellular processes. LÄS MER

  3. 2. Functional characterization of the secretory pathway and the role of COPI vesicles

    Författare :Johan Hiding; Göteborgs universitet; []
    Nyckelord :Golgi; Phosphoinositides; Fusion; COPI; ARF1; Proteomics; ER;

    Sammanfattning : In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How intracellular transport takes place has been the focus of cell biology research for a long time. LÄS MER

  4. 3. Membrane lipids and their transfer proteins in β-cells

    Författare :Beichen Xie; Olof Idevall-Hagren; Anders Tengholm; Jen Liou; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ca2 ; PKC; E-Syt1; TMEM24; ER-PM contact; PI 4; 5 P2; phosphoinositides; β-cell; insulin; optogenetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. LÄS MER

  5. 4. Studies on 15-lipoxygenase in dendritic cells and leukotriene receptors in Hodgkin lymphoma

    Författare :Frida Schain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Classical Hodgkin lymphoma (cHL) is histologically characterized by a minority of malignant cells, the so-called Hodgkin-Reed Sternberg (H-RS) cells, surrounded by inflammatory cells such as T lymphocytes, eosinophils, macrophages and mast cells. It is generally believed that various molecules released by the H-RS cells are of major importance in the pathophysiology of cHL. LÄS MER

  7. 5. Plant Phosphoinositide Kinases. A Study of PtdIns 4-kinases and a PtdIns 4-phosphate 5-kinase

    Författare :Tomas Westergren; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; regulation; plant phosphorylation; plasma membrane; lipid kinase; divalent ion; phosphoinositide; substrate specificity; Plant biochemistry; Växtbiokemi;

    Sammanfattning : Phosphoinositides are of particular interest in signal transduction processes as they can be sequentially phosphorylated and used as precursors for the intracellular messengers inositol trisphosphate (InsP3) and diacylglycerol (DAG) that in turn affects calcium levels and protein kinase cascades, eventually leading to a physiological response. The activity and regulation of PtdIns 4-kinases and PtdInsP kinase was studied. LÄS MER