Sökning: "phosphoinositide kinase"

Visar resultat 6 - 10 av 26 avhandlingar innehållade orden phosphoinositide kinase.

  1. 6. Kinase cascades in the regulation of glucose homeostasis

    Författare :Tatiana L Steiler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; insulin resistance; T2DM; hyperglycemia; high fat diet; glucose transport; PI3K-; MAPK- and AMPK-signaling pathways; AMPKgamma3;

    Sammanfattning : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. LÄS MER

  3. 7. Insulin Signalling and Regulation of Protein Kinase B in Adipocytes

    Författare :Olga Göransson; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; PDK1; PKB; diabetes; insulin; adipocyte;

    Sammanfattning : Insulin resistance is a hallmark of type 2 diabetes, an increasingly common disorder. The cause of insulin resistance is supposedly failures in the processes used by insulin to signal to the interior of its target cells. These failing steps are still unknown, most probably because of incomplete knowledge of how the insulin signals are transmitted. LÄS MER

  4. 8. Receptor tyrosine kinase c-Kit signalling in hematopoietic progenitor cells

    Författare :Charlotte Edling; Bengt Hallberg; Pontus Aspenström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RTK; c-Kit; MAPK; PI3K; PKC; hematopoietic cells; proliferation; differentiation; apoptosis; Pathology; Patologi;

    Sammanfattning : The receptor tyrosine kinase (RTK) c-Kit is expressed in hematopoietic stem and progenitor cells, mast cells and in several non-hematopoietic tissues. In the hematopoietic system c-Kit and its ligand Steel Factor (SF, aka Stem Cell Factor) are critical for proliferation, survival and differentiation. LÄS MER

  5. 9. Complement receptor-mediated signal transduction in human neutrophils : A role for protein kinase C in the phagocytic process

    Författare :Maria Fällman; Claes B. Wollheim; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The neutrophil granulocyte comprises the first line of human defense against invading microorganisms. A versatile motile machinery enables the cell to migrate to the inflammatory site and there engulf and destroy the pathogens by phagocytosis. LÄS MER

  7. 10. Molecular studies of intra-oocyte phosphatidylinositol 3 kinase (PI3K) signaling pathway in controlling female fertility

    Författare :Pradeep Reddy Dubbaka Venu; Kui Liu; Evelyn Telfer; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primordial follicles; Oocyte; PI3K; Biochemistry; Biokemi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : The primordial follicle pool is the main source of developing follicles in the ovary. The length of reproductive life and the onset of menopause are governed by the amount of primordial follicles in the ovary. LÄS MER