Sökning: "phosphodiesterase type 5 inhibitors"

Hittade 3 avhandlingar innehållade orden phosphodiesterase type 5 inhibitors.

  1. 1. Cyclic guanosine 3', 5'-monophosphate : studies on synthesis and efflux from hepatocytes, liver slices and cerebellar slices and on serotonin-mediated cGMP synthesis in human platelets

    Författare :Marie-Louise Tjörnhammar; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The present study established the existence of a carrier mediated transport of 3'5' cGMP from rat liver slices, hepatocytes and cerebellar slices in which the cellular levels of 3'5' cGMP were elevated by application of appropriate stimuli and inhibitors of the 3'5' cyclic nucleotide phosphodiesterase. The carrier is specific for 3'5' cGMP as opposed to 3'5' cAMP. LÄS MER

  3. 2. Vardenafil and methylarginines in pulmonary hypertension

    Författare :Anna Sandqvist; Gerhard Wikström; Jörn Schneede; Amrita Ahluwalia; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vardenafil; pulmonary hypertension; pharmacokinetics; haemodynamics; right heart catheterization; adenosine; dimethylarginines; phosphodiesterase type 5 inhibitors; endothelin receptor antagonists; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Background: Pulmonary hypertension (PH) is a rare condition characterized by endothelial dysfunction and vascular remodelling, leading to increased pulmonary vascular resistance (PVR) and right ventricular heart failure. Endothelial dysfunction is associated with an imbalance between vasoconstrictor compounds, such as endothelin and thromboxane A2, and vasodilator compounds, such as prostacyclin and nitric oxide (NO). LÄS MER

  4. 3. Ammonia assimilation and nitrogen fixation in phototrophic bacteria : studies on glutamine synthease and the metabolic regulation of nitrogenase in Rhodospirillum rubrum

    Författare :Abdelhamid Soliman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The phototrophic bacteria and a few other species, are able to control nitrogen fixation on the metabolic level. This is a fast and reversible mechanism, which “switches off and on” the nitrogenase activity in response to the accessibility of combined nitrogen, the energy supply and the level of oxygen in the medium. LÄS MER