Sökning: "phosphatidylinositol 3-kinase"
Visar resultat 21 - 25 av 44 avhandlingar innehållade orden phosphatidylinositol 3-kinase.
21. Effects of prenatal IL-6 exposure and hyperinsulinemia on neuroendocrine regulation
Sammanfattning : Prenatal exposure to infection is associated with several neuroendocrine disorders. We therefore wanted to elucidate if cytokines, generated in response to maternal infection, play a key mechanistic role in this associations. LÄS MER
22. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
Sammanfattning : The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. LÄS MER
23. Structural and Functional Aspects of β1 Integrin Signalling
Sammanfattning : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. LÄS MER
24. Organ-specific mechanisms of vascular development in the mesentery
Sammanfattning : Understanding how the vascular systems are formed has significant clinical importance. General mechanisms underlying vascular development have been extensively studied during the past decades. However, the mechanisms regulating the development and function of the blood and lymphatic vessels in specific organs are poorly understood. LÄS MER
25. Signaling pathways in the development of female germ cells
Sammanfattning : Primordial follicles are the first small follicles to appear in the mammalian ovary. Women are born with a fixed number of primordial follicles in the ovaries. Once formed, the pool of primordial follicles serves as a source of developing follicles and oocytes. LÄS MER