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1. 1. Signalling to Activation of Cytosolic Phospholipase A2 and Arachidonate Release in Macrophages

   Författare :Gösta Hiller; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; signal transduction; dexamethasone; macrophages; phospholipase C; phosphatidylinositol 3-kinase; mitogen-activated protein kinases; cytosolic phospholipase A2; arachidonic acid; Histology; cytochemistry; histokemi; cytokemi; tissue culture; Histologi; vävnadskultur; histochemistry;

   Sammanfattning : Eicosanoids include prostaglandins, thromboxanes and leukotrienes, which are arachidonic acid oxygenation products. These lipids make important contributions to the signs and symptoms of inflammatory diseases. LÄS MER

3. 2. Cyclic Nucleotide Phosphodiesterase 3B: Regulation in rat adipocytes and 3T3-L1 cells

   Författare :Tova Landström; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3T3-L1 TNF-alpha; adipocyte; insulin; p70S6 kinase; mitogen-activated protein kinase; protein kinase B; phosphatidylinositol-3 kinase; phosphodiesterase 3B; cAMP; lipolysis; phosphorylation; signal transduction; Biochemistry; Metabolism; Biokemi; metabolism;

   Sammanfattning : Insulin stimulation of rat adipocytes results in phosphorylation and activation of the cyclic nucleotide phosphodiesterase 3B (PDE3B), a key enzyme in the antilipolytic signalling pathway of this hormone. In this thesis, the site phosphorylated in PDE3B upon stimulation of rat adipocytes with insulin and/or the beta-adrenergic agonist, isoproterenol is identified. LÄS MER

4. 3. Collagen-binding integrin α2β1 activity in vivo and in vitro : Effects of platelet-derived growth factor-BB

   Författare :Karina Åhlén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin α2β1; PDGF-BB; fibroblast; interstitial fluid pressure; cytoskeletal interaction; phosphatidylinositol 3-kinase; [Ca2 ]i; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

   Sammanfattning : The expression of integrins by two cell clones from a rat colon carcinoma was investigated. Cloned cells that gave rise to regressive tumors, but not cells that gave rise to progressive, lethal, tumors, adhered to interstitial collagens through the integrin α2β1, although both cell types expressed it. LÄS MER

5. 4. Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in mammalian ovarian follicle activation and development

   Författare :Singareddy Rajareddy; Kui Liu; Anneli Stavreus-Evers; Umeå universitet; []
   Nyckelord :oocyte; follicular development; P13K pathway; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : The intra-oocyte signaling pathways that control oocyte growth and early follicular development are largely unknown. The aim of this thesis was to investigate the regulation and functions of phosphatidylinositol 3 kinase (PI3K) pathway in the oocyte, focusing in the roles of Foxo3a, p27, and Pten (phosphatase and tensin homolog deleted on chromosome ten). LÄS MER

7. 5. Molecular studies of intra-oocyte phosphatidylinositol 3 kinase (PI3K) signaling pathway in controlling female fertility

   Författare :Pradeep Reddy Dubbaka Venu; Kui Liu; Evelyn Telfer; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primordial follicles; Oocyte; PI3K; Biochemistry; Biokemi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

   Sammanfattning : The primordial follicle pool is the main source of developing follicles in the ovary. The length of reproductive life and the onset of menopause are governed by the amount of primordial follicles in the ovary. LÄS MER