Avancerad sökning

Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Phosphatidylethanol - formation and degradation in blood and organs

   Författare :Steina Aradottir; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diagnostik; Public health; Diagnostics; organs; blood; HPLC; in vitro; in vivo; human; rat; phosphatidylethanol; phospholipase D; alcohol; ethanol; epidemiology; Folkhälsa; epidemiologi;

   Sammanfattning : Phosphatidylethanol (PEth) is an abnormal phospholipid formed exclusively by the action of phospholipase D (PLD) in the presence of ethanol. The degradation of PEth is slow and due to its accumulation in some cells the possibility to use PEth as marker of ethanol intake has been proposed. LÄS MER

3. 2. Phosphatidylethanol in blood as a marker of alcohol abuse

   Författare :Arthur Varga; Associativ inlärning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PKC; MCV; ELSD; HPLC; red blood cell; phospholipase D; phosphatidylethanol; ethanol; alcohol abuse; state marker; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Biological markers offer a way of assessing ethanol intake and determining whether a health problem is alcohol related. This study investigated the use of phosphatidylethanol (PEth) in blood as a new marker of alcohol abuse. LÄS MER

4. 3. Methodological and clinical evaluation of the alcohol marker phosphatidylethanol (PEth)

   Författare :Lisa Walther; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :alcohol; alcohol marker; alcohol use disorder; phosphatidylethanol; PEth; phosphatidylcholine; alcohol use; gastric bypass; LC-MS MS;

   Sammanfattning : .... LÄS MER

5. 4. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption

   Författare :Andrea deBejczy; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol dependence; mirtazapine; varenicline; org 25935; alcohol markers; phosphatidylethanol; randomized controlled clinical trials RCT ; treatment; glycine transporter inhibitor; nAChR;

   Sammanfattning : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. LÄS MER

7. 5. Biomarkers and risk of intracerebral hemorrhage : population-based studies in northern Sweden

   Författare :Kristina Johansson; Marcus Lind; Lars Johansson; Jan-Håkan Jansson; Arne Lindgren; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intracerebral hemorrhage; hemorrhagic stroke; factor XII; D-dimer; von Willebrand factor; ABO blood groups; phosphatidylethanol; alcohol; risk markers; biomarkers; Medicine; medicin;

   Sammanfattning : BackgroundIntracerebral hemorrhage (ICH) is a disease associated with a high morbidity and mortality and treatment options for the condition are limited. Even though an ICH event usually comes as a surprise to the affected individual, pathogenetic processes often have occurred before the sudden ICH event and may have preceded disease onset by years. LÄS MER