Sökning: "phenotypic modulation"

Visar resultat 6 - 10 av 30 avhandlingar innehållade orden phenotypic modulation.

  1. 6. Regulation of the vascular smooth muscle cell phenotype

    Författare :Henrik Lindskog; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; embryonic stem cells; vascular smooth muscle cell; smooth muscle cell; pericyte; phenotypic modulation; lipoma preferred partner; ectra-cellular matrix; zinc finger protein 148;

    Sammanfattning : Smooth muscle cells (SMC) are present in many internal organs such as the blood vessels and the gastrointestinal channel. Their main functions are to provide stability to the tissue and to provide contractile capability. SMC are not terminally differentiated but can switch between several phenotypes, which is also known as phenotypic modulation. LÄS MER

  3. 7. Mesenchymal stromal/stem cells : expansion, engraftment and immune modulation

    Författare :Håkan Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Due to their production of hematopoietic growth factors and their immunomodulatory capacity, bone marrow-derived mesenchymal stromal/stem cells (MSC), are a promising tool in the procedure of hematopoietic stem cell transplantation (HSCT). Seven patients undergoing allogeneic HSCT were co-infused with MSC. LÄS MER

  4. 8. Modulation of mononuclear phagocyte function in the dissemination of Toxoplasma gondii

    Författare :Arne L. ten Hoeve; Antonio Barragan; Nicolas Blanchard; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apicomplexa; dendritic cell; macrophage; intracellular signaling; parasite-derived effector protein; chemotaxis; leukocyte migration; transcription factor; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Toxoplasma gondii is an obligate intracellular Apicomplexan parasite that could possibly infect all warm-blooded animals. Acute infections with T. LÄS MER

  5. 9. Novel markers for smooth muscle cell modulation in vascular injury and disease

    Författare :Urszula Rykaczewska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during disease development. With remarkable plasticity, SMCs act as early responders to vessel wall injury, where by activating molecular mechanisms, including phenotypic modulation and transdifferentiation, they counteract detrimental stimuli and aim to restore vascular homeostasis. LÄS MER

  7. 10. Modulation of adhesion molecules on leukocytes during clinical and experimental hemodialysis : endothelial cell interacions

    Författare :Pia Thylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adhesion; adhesion molecules; complement; endothelial cells; hemodialysis; integrins; interleukin; leukocytes; selectins.;

    Sammanfattning : In patients on hemodialysis the sequential steps required for adhesion molecule mediated adherence of leukocytes to endothelial cells are unphysiologically disrupted since cell activation with subsequent alterations in adhesion molecule phenotypes takes place in the extracorporeal circuit far away from the respective endothelial cell ligand. The aims of the present investigations were to study the changes in adhesion molecule phenotypes on inflammatory cells induced by clinical and experimental hemodialysis and the consequences with regard to the capacity of the cells to adhere to endothelial cells. LÄS MER