Sökning: "phenotypic modulation"

Visar resultat 16 - 20 av 30 avhandlingar innehållade orden phenotypic modulation.

  1. 16. Studies on the functional interaction of translation initiation factor IF1 with ribosomal RNA

    Författare :Jaroslav Belotserkovsky; Leif Isaksson; Diarmaid Hughes; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome; rRNA mutation; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Translation initiation factor IF1 is a small, essential and ubiquitous protein factor encoded by a single infA gene in bacteria. Although several important functions have been attributed to IF1, the precise reason for its indispensability is yet to be defined. LÄS MER

  3. 17. Studies on extracellular matrix proteins in vascular disease

    Författare :Åsa Ström; Kärlväggsbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; smooth muscle cells; osteopontin; extracellular matrix; atherosclerosis;

    Sammanfattning : The composition of the vascular extracellular matrix (ECM) is altered during remodeling conditions such as atherosclerosis. The changed ECM regulates events that are important for the progression of disease including smooth muscle cell (SMC) behaviour and collagen fiber formation. LÄS MER

  4. 18. Role of GPS2 in epigenome alterations linked to metaflammation

    Författare :Zhiqiang Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein pathway suppressor 2 (GPS2) is a key component of the HDAC3 co-repressor complex that has been earlier implicated in cholesterol homeostasis and anti-inflammatory crosstalk. LÄS MER

  5. 19. Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors

    Författare :Neivis Tormo-Badia; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. LÄS MER

  7. 20. Human natural killer cell activation and differentiation in health and viral infection

    Författare :Niklas Björkström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are lymphocytes that belong to the innate immune system. They are important for the early defense against viral infections and provide tumor Immune surveillance against both solid tumors and leukemias as well as in settings of hematopoietic stem cell transplantation. LÄS MER