Sökning: "phenotypic modulation"

Visar resultat 11 - 15 av 30 avhandlingar innehållade orden phenotypic modulation.

  1. 11. The vascular response to oxidative and mechanical stress

    Författare :Federico Ben Calara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; inflammation; smooth muscle cells; low density lipoprotein; oxidized low density lipoprotein; lipid peroxidation; antioxidants; HDL; caveolae; phenotype modulation; balloon injury; immunization; growth factors;

    Sammanfattning : Atherosclerosis is a chronic inflammatory disease, which is one of leading causes of death in the Western world. The study of the vascular response to initiators of inflammation can lead us to a better understanding of the basic mechanisms that lead to the development of this disease. Balloon injured arteries develop a neointima. LÄS MER

  3. 12. Extracellular matrix-mediated signaling in the regulation of vascular smooth muscle cell phenotype and function

    Författare :Joy Roy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease is the leading cause of mortality in the world. Even though death rates are today dropping in the developed countries, disability due to the disease is rising worldwide. The major portion of cardiovascular disease associated deaths is due to occlusive atherosclerotic lesions. LÄS MER

  4. 13. Transcriptional control in the vascular wall. Actin-responsive coactivators and smooth muscle transcripts

    Författare :Katarzyna Krawczyk; Cellulär biomekanik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cardiovascular disease (CVD) is the leading cause of death globally. In the European Union (EU) alone, CVD accounts for 1.8 million deaths each year. CVD is a group of disorders involving the heart and the blood vessels. LÄS MER

  5. 14. Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2

    Författare :Anirban Bhattachariya; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; portal vein; resistance artery; myogenic tone; PYK2; calcium; microRNA;

    Sammanfattning : Intraluminal pressure has a significant impact on vascular adaptability, phenotype and regulation of blood flow and pressure. On one hand, increased pressure/stretch for a prolonged time can cause structural changes in vessel wall; on the other hand, lack of pressure/stretch can promote a phenotype shift. LÄS MER

  7. 15. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

    Författare :Azra Alajbegovic; Molekylär kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Vascular smooth muscle cells VSMC ; cell phenotype; microRNA; Aneurysm; hypertension; Actin polymerization; GATA6; MRTFA; Vascular disease;

    Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER