Sökning: "phenotypic integration"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden phenotypic integration.
1. Behaviour under predation risk - antipredator strategies, behavioural syndromes and sex-specific responses in aquatic prey
Sammanfattning : In many natural ecosystems, predation is well recognized as a strong evolutionary force, and predator-mediated selection has been demonstrated to induce changes in prey morphology, life history and behaviour. In my thesis, I have focused on behavioural responses in aquatic prey under the risk of predation. LÄS MER
2. In vivo properties of neural stem cells after transplantation into the rat brain-Studies of phenotypic differentiation and functional integration using cell-specific labelling and electrophysiological techniques
Sammanfattning : In the present thesis, we have examined the in vivo properties of in vitro expanded human and rat neural stem-and progenitor cells after transplantation into the neonatal and adult rat brain. The survival and differentiation of the grafted cells were assessed using species-specific antisera, and pre-labelling with the reporter gene green fluorescent protein (GFP). LÄS MER
3. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair
Sammanfattning : The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted into rodent and non-human primate models of PD. LÄS MER
4. Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome
Sammanfattning : Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) is transcribed to messenger ribonucleic acid (mRNA), and then translated into proteins; dysfunction in any of these processes may contribute to the development of disease. LÄS MER
5. A phenotypic study of a unique respiratory strain of Saccharomyces cerevisiae and its application in protein production
Sammanfattning : During aerobic growth at high glucose concentrations, the yeast Saccharomyces cerevisiae prefers to catabolise glucose through fermentation rather than through respiration. Previously fully respiratory growth could only be achieved when a low external glucose concentration was maintained, in fed-batch and continuous cultures, but since the development of the respiratory strain, TM6*, in our laboratory this can now be achieved even at high external glucose concentration. LÄS MER
