Sökning: "phase 3 trials"

Visar resultat 21 - 25 av 62 avhandlingar innehållade orden phase 3 trials.

  1. 21. Control of sexually transmitted infections in a high prevalence region : HIV, syphilis and HBV among young adults and preparation for HIV vaccine trials in Mozambique

    Författare :Nelson Tembe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mozambique is one of the countries with a high burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis. HIV seroprevalence in adults was estimated to be 11.5% in 2009, syphilis prevalence among women was estimated to be 5.7% in 2010 and an estimated national HBV prevalence of above 8%. LÄS MER

  3. 22. Porcelain veneering of titanium : clinical and technical aspects

    Författare :Per Haag; Malmö högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Guld- och andra legeringar har i många år använts som material vid framställning av kronor och broar för ersättning av skadade eller förlorade tänder. Emellertid har tvivel uppstått kring lämpligheten av att använda guldlegeringar i tandersättningar, då guld har visat sig kunna ge biverkningar i form av allergiska reaktioner. LÄS MER

  4. 23. On neonatal asphyxia : clinical and animal studies including development of a simple, safe method for therapeutic hypothermia with global applicability

    Författare :Linus Olson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recent randomized clinical trials show that hypothermia can decrease brain dysfunction in newborn infants at risk for hypoxic-ischemic encephalopathy. One goal of the present study was to develop an alternative to current relatively complex and expensive cooling methods dependent on electricity and continuous water supply. LÄS MER

  5. 24. Covariate Model Building in Nonlinear Mixed Effects Models

    Författare :Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Sammanfattning : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. LÄS MER

  7. 25. On Automation in Anesthesia

    Författare :Kristian Soltesz; Institutionen för reglerteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; PID conrol; medical applications;

    Sammanfattning : The thesis discusses closed-loop control of the hypnotic and the analgesic components of anesthesia. The objective of the work has been to develop a system which independently controls the intravenous infusion rates of the hypnotic drug propofol and analgesic drug remifentanil. LÄS MER