Sökning: "phase 3 trials"

Visar resultat 11 - 15 av 62 avhandlingar innehållade orden phase 3 trials.

  1. 11. Best Practice Physiotherapy for Patients with Low Back Pain in Primary Care : Clinical Outcomes and Explanatory Factors

    Författare :Maria Fors; Allan Abbott; Paul Enthoven; Eva Rasmussen Barr; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Background: Clinical practice guidelines provide general recommendations informing best practice physiotherapy for low back pain (LBP). Despite increased research on LBP, the recommendations have barely changed over the last few decades and the burden of LBP remains. LÄS MER

  3. 12. A radical view of haemoglobin - protein engineering and characterisation

    Författare :Marie Grey; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; His-Gln tagging; protein purification; blood substitutes; radical scavenging; superoxide dismutase; E. coli; diglobin; Haemoglobin; protein engineering; aqueous two-phase systems; hydrophobic interaction chromatography;

    Sammanfattning : In recent years shortages of donated blood have become a growing problem for health care systems world-wide. Blood substitutes based on human haemoglobin (Hb) could potentially ameliorate this situation. However, clinical trials have indicated problems due to e.g. LÄS MER

  4. 13. Brain distribution of a bispecific antibody targeting Aβ

    Författare :Gustavsson Tobias; Dag Sehlin; Stina Syvänen; Paul O'Callaghan; Danica Stanimirovic; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; blood-brain barrier; single-photon emission computed tomography SPECT ; bispecific antibody; immunotherapy; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

    Sammanfattning : Alzheimer’s disease (AD) is characterised by aberrant protein aggregation in the brain with subsequent synaptic loss, neuroinflammation, and brain atrophy that ultimately clinically manifests as cognitive impairment. Histopathological findings in AD are extracellular plaques of the protein amyloid-beta (Aβ), Aβ in blood vessels (CAA), and intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau. LÄS MER

  5. 14. The CD40 Receptor - Target,Tool and Technology

    Författare :Peter Ellmark; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; SPIRE; mammalian; library; cDNA; selection; receptor revision; phage display; scFv; human; CD40; antibodies;

    Sammanfattning : CD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. LÄS MER

  7. 15. Recurrent stroke : risk factors, predictors and prognosis

    Författare :Johanna Pennlert; Marie Eriksson; Per-Gunnar Wiklund; Bo Carlberg; Hélène Pessah-Rasmussen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; risk factors; atrial fibrillation; anticoagulant; antiplatelet; intracerebral hemorrhage; stroke recurrence; socioeconomic status; medicin; Medicine;

    Sammanfattning : Background Many risk factors for stroke are well characterized and might, at least to some extent, be similar for first-ever stroke and for recurrent stroke events. However, previous studies have shown heterogeneous results on predictors and rates of stroke recurrence. LÄS MER