Sökning: "phase 1 trials"

Visar resultat 1 - 5 av 59 avhandlingar innehållade orden phase 1 trials.

  1. 1. Patients in Clinical Cancer Trials : Understanding, Motivation and Hope

    Författare :Tove Godskesen; Ulrik Kihlbom; Peter Nygren; Karin Nordin; Peter Strang; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Adults; Clinical trials; Phase 1 trials; Phase 3 trials; Patient information; Patient education; Informed consent; Hope; cancer; adults; clinical trials; phase 1 trials; phase 3 trials; patient information; patient education; informed consent; hope;

    Sammanfattning : The overall aim of this thesis was to study participants' understanding of clinical cancer trials,and their motivation for participation. Of particular interest was the question of whether thepatients hoped for a cure resulting from the trial. LÄS MER

  2. 2. EM Estimation in Phase Type Models

    Författare :Marita Olsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :phase type distributions; coxian distribution; EM algorithm; I-divergence; density estimation; right censoring; interval censoring; standard error estimation; asymptotic theory; jackknife; relapse clinical trials; survival data; hidden Markov chain; I-divergence;

    Sammanfattning : This thesis consists of four articles whose theme in common is the class of phase type distributions. In the first article an EM algorithm is presented to estimate the parameters of a phase type distribution of fixed order. Also, it is shown that the algorithm can be used to approximate other continuous distributions by phase type distributions. LÄS MER

  3. 3. Ligand-induced structural changes in HIV-1 envelope glycoprotein

    Författare :Selina Poon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HIV-1;

    Sammanfattning : The first step in HIV - 1 entry is the interaction between viral envelope glycoprotein gp120 and CD4 receptor on permissive host cells. The interaction initiates a series of sequential conformational rearrangements that exposes epitopes involved in interaction with co - receptors. LÄS MER

  4. 4. A contribution to the design and analysis of phase III clinical trials

    Författare :Vera Lisovskaja; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :;

    Sammanfattning : Clinical trials are an established methodology for evaluation of the effects of a new medical treatment. These trials are usually divided into several phases, namely phase I through IV. The earlier phases (I and II) are relatively small and have a more exploratory nature. LÄS MER

  5. 5. On the Extraction of Essential Oils by Supercritical Carbon Dioxide and its Influence on the Mesomorphic Phase Structures

    Författare :José da Cruz Francisco; Kemiska institutionen; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Natural oils; fats and waxes technology; Naturliga oljor; fetter; vax; Kemiteknik och kemisk teknologi; Chemical technology and engineering; Livsmedelsteknik; Food and drink technology; phase behavior; soybean lecithin; monoolein; cineole; terpenes; eucalyptus; extraction; Essential oils; supercritical carbon dioxide;

    Sammanfattning : A comparison of essential oils from leaves of Eucalyptus camaldulensis Dehn. obtained by hydrodistillation (HD) and supercritical carbon dioxide (SC-CO2) extraction is presented. Selected major components of the oils showed a predominance of higher molecular weight components in the SC-CO2 extracts than in those obtained by HD. LÄS MER