Sökning: "pharmacovigilance"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet pharmacovigilance.

  1. 11. PageRank in Evolving Networks and Applications of Graphs in Natural Language Processing and Biology

    Författare :Christopher Engström; Sergei Silvestrov; Raimondo Manca; Mälardalens högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mathematics Applied Mathematics; matematik tillämpad matematik;

    Sammanfattning : This thesis is dedicated to the use of graph based methods applied to ranking problems on the Web-graph and applications in natural language processing and biology.Chapter 2-4 of this thesis is about PageRank and its use in the ranking of home pages on the Internet for use in search engines. LÄS MER

  3. 12. Drug research and development - case scenarios, development process, risks and benefits

    Författare :Ivor Cowlrick; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery and development; benefit and risk; decision making; entrepreneurship; open innovation;

    Sammanfattning : BACKGROUND AND AIMS. Drug development has been classically associated with large pharmaceutical companies developing ‘blockbuster’ drugs aimed at large patient populations through high market penetration and multiple indication life cycle management. Higher costs and lower output have rendered this model inefficient and unsustainable. LÄS MER

  4. 13. Prostate Cancer; Metabolic Risk Factors, Drug Utilisation, Adverse Drug Reactions

    Författare :Birgitta Grundmark; Lars Holmberg; Björn Zethelius; Gunnar Engström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Epidemiology; Pharmacoepidemiology; Metabolic Syndrome; Selenium; Smoking; hOGG1; MnSOD; Competing Risk; Adherence; Persistance; Medical Possession Ratio; MPR; Signal Detection; PRR; proportional reporting ratio; ULSAM; PcBaSE; EudraVigilance; SPDR; Swedish Prescribe Drug Registry; NPCR; National Prostate Cancer Registry; SDR; Signal; disproportionality analysis; PRR-TA; EudraVigilance; Epidemiology; Epidemiologi; Kirurgi; särskilt urologi; Urology; Oncology; Onkologi; Geriatrics; Geriatrik;

    Sammanfattning : Increased possibilities during the last decades for early detection of prostate cancer have sparked research on preventable or treatable risk factors and on improvements in therapy. Treatments of the disease still entail significant side effects potentially affecting men during the rest of their lives. LÄS MER

  5. 14. Sex differences in adverse drug events from cardiovascular medicines in routine care

    Författare :Diana Rydberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In preventive drug treatment of cardiovascular disease, adverse drug effects often lead to suboptimal compliance with a risk of disability and shorter life expectancy. The overall aim of this thesis was to assess the nature and extent of adverse drug events (ADEs) from cardiovascular drugs in both women and men treated in routine care. LÄS MER

  7. 15. Real-world outcomes in oncology : assessing the value of rewardable innovation

    Författare :Nahila Justo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recent years have seen a remarkable expansion of therapeutic options available for many forms of cancer. Evidence for the efficacy of these treatments have mainly come from randomized controlled trials, however questions often remain regarding the actual use, effectiveness and value of innovative therapies when used under the circumstances of routine clinical practice. LÄS MER