Sökning: "pharmacometric"

Visar resultat 6 - 10 av 45 avhandlingar innehållade ordet pharmacometric.

  1. 6. Pharmacometric Modeling in Rheumatoid Arthritis

    Författare :Brigitte Lacroix; Lena Friberg; Mats Karlsson; Maria Laura Sargentini-Maier; Kosmas Kretsos; Ekaterina Gibiansky; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; PKPD; immunogenicity; ACR; IPPSE; certolizumab pegol;

    Sammanfattning : Biologic therapies have revolutionized the treatment of rheumatoid arthritis, a common chronic inflammatory disease, mainly characterized by the chronic inflammation of the joints. The activity and progression of the disease are highly variable, both between subjects and between the successive assessments for the same subject. LÄS MER

  3. 7. Garnishing the smorgasbord of pharmacometric methods

    Författare :Henrik Bjugård Nyberg; Andrew Hooker; Johannes Schropp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; saddle points; nonidentifiability; modelling and simulation; tuberculosis; ethionamide; bioequivalence; model-integrated evidence; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The smorgasbord of methods that we use within the field of pharmacometrics has developed steadily over several decades and is now a well-laid-out buffet. This thesis adds some garnish to the table in the form of small improvements to the handling of certain problems. LÄS MER

  4. 8. Pharmacometric Models in Anesthesia and Analgesia

    Författare :Marcus Björnsson; Ulrika Simonsson; Mats Karlsson; Leonid Gibiansky; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Anesthesia; Analgesia; Dropout; NONMEM; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Modeling is a valuable tool in drug development, to support decision making, improving study design, and aid in regulatory approval and labeling. This thesis describes the development of pharmacometric models for drugs used in anesthesia and analgesia. LÄS MER

  5. 9. Dose Adaptation Based on Pharmacometric Models

    Författare :Johan Wallin; Mats Karlsson; Lena Friberg; Maria Garrido; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Many drugs exhibit major variability in both pharmacokinetic (PK) and pharmacodynamic (PD) parameters that prevents the use of the same dose for all patients. Variability can occur both between patients (IIV) as well as within patients over the course of time (IOV). LÄS MER

  7. 10. Pharmacometric Models to Improve Treatment of Tuberculosis

    Författare :Elin M Svensson; Mats O Karlsson; Maria C Kjellsson; Ulrika S H Simonsson; N. L’Ntshotsholé (Shasha) Jumbe; Uppsala universitet; []
    Nyckelord :pharmacokinetics; pharmacodynamics; population approach; nonlinear mixed-effects models; multidrug-resistant tuberculosis; bedaquiline; antiretroviral; drug-drug interactions; time-to-event; albumin; Klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. LÄS MER