Sökning: "pharmacometric"
Visar resultat 11 - 15 av 44 avhandlingar innehållade ordet pharmacometric.
11. Pharmacometric Methods and Novel Models for Discrete Data
Sammanfattning : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. LÄS MER
12. Pharmacometric models in the development of biological medicinal products
Sammanfattning : Biological medicinal products (BMPs) are a successful class of drugs that are indicated in numerous diseases. Common among them is that complexities associated with their manufacture and analysis lead to a high cost compared to small-molecular weight drugs. LÄS MER
13. Pharmacometric models to inform dose selection and study design : Applied in hemophilia and tuberculosis
Sammanfattning : While tuberculosis is a global pandemic, hemophilia is a rare disease which many have not heard of. Due to tuberculosis mainly being a problem in developing countries and hemophilia being a rare disease, they are not as heard of as other diseases such as cancer or metabolic diseases which are on the rise in Western societies. LÄS MER
14. Pharmacometric Evaluation of Biomarkers to Improve Treatment in Oncology
Sammanfattning : Cancer is a family of many different diseases with substantial heterogeneity also within the same cancer type. In the era of personalized medicine, it is desirable to identify an early response to treatment (i.e., a biomarker) that can predict the long-term outcome with respect to both safety and efficacy. LÄS MER
15. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling
Sammanfattning : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. LÄS MER