Sökning: "pharmacokinetics"
Visar resultat 6 - 10 av 305 avhandlingar innehållade ordet pharmacokinetics.
6. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy
Sammanfattning : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. LÄS MER
7. Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT
Sammanfattning : N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the human consciousness using brain imaging techniques. LÄS MER
8. Pharmacokinetics and dosimetry in intraperitoneal radioimmunotherapy with 211At
Sammanfattning : The prognosis for patients diagnosed with disseminated cancer is often poor. Radioimmunotherapy (RIT) is a new approach to treat disseminated disease. The aim is to target tumor cells with monoclonal antibodies (mAbs) labeled with radionuclides which release cytotoxic particle radiation upon decay. The radionuclide 211At, with half-life 7. LÄS MER
9. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics
Sammanfattning : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. LÄS MER
10. Mechanistic Based Pharmacokinetic-Pharmacodynamics models for Drug Interactions and Disease Population Predictions
Sammanfattning : Therapeutic dose of a medication refers to the quantity of a drug required to produce a pharmacological effect without causing unacceptable adverse events. Dose selection in the clinical setting is not straight forward due to various factors, including specific patient factors such as age, sex, weight, genetic variants and renal/hepatic function, as well as external factors such as food and co-medication, all of which can influence the efficacy and safety of a drug. LÄS MER