Sökning: "pharmacokinetics portacaval shunt pharmacodynamics hepatic encephalopathy enantiomers drug safety drug disposition citalopram antidepressants brain microdialysis behaviour venlafaxine Pharmacological sciences pharmacognosy pharmacy toxicology Farmakologi farmakognosi farmaci toxikologi"

Hittade 1 avhandling innehållade orden pharmacokinetics portacaval shunt pharmacodynamics hepatic encephalopathy enantiomers drug safety drug disposition citalopram antidepressants brain microdialysis behaviour venlafaxine Pharmacological sciences pharmacognosy pharmacy toxicology Farmakologi farmakognosi farmaci toxikologi.

1. 1. Antidepressant drug effects in vivo: Focus on pharmacokinetic and pharmacodynamic responses in different experimental paradigms

   Författare :Cecilia Wikell; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; portacaval shunt; pharmacokinetics; pharmacodynamics; hepatic encephalopathy; enantiomers; drug safety; drug disposition; citalopram; antidepressants; brain microdialysis; behaviour; venlafaxine; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : Pharmacokinetic and pharmacodynamic activities of the antidepressants venlafaxine (VEN) and citalopram (CIT) were investigated in the portacaval shunted (PCS) rat, a model of chronic hepatic encephalopathy (HE), and normal/control rats. The levels of VEN in serum and brain were higher in PCS rats than in controls after a single injection and chronic treatment with VEN (10 mg/kg). LÄS MER