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  1. 1. Resistance to phagocytosis in Streptococcus pyogenes

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Fredric Carlsson; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; Medicine human and vertebrates ; Medicin människa och djur ; phagocytosis; innate immunity; complement; Streptococcus pyogenes; M protein;

    Sammanfattning : Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. LÄS MER

  2. 2. Mechanisms of phagocytosis resistance in Streptococcus pyogenes

    Detta är en avhandling från Heike Kotarsky, MIG, Sölvegatan 17, 223 62 LUND

    Författare :Heike Kotarsky; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; fibrinogen; FHL-1; Factor H; M protein; Streptococcus pyogenes; phagocytosis;

    Sammanfattning : A distinguishing feature of Streptococcus pyogenes (GAS) is their ability to resist phagocytosis in whole human blood in the absence of type-specific antibodies, a property that is dependent on the expression of the surface associated M proteins. A common characteristic of M proteins is their interaction with a variety of host proteins including the complement regulatory protein factor H (FH) and fibrinogen that plays a key role in coagulation. LÄS MER

  3. 3. Mechanisms involved in macrophage phagocytosis of apoptotic cells

    Detta är en avhandling från Umeå : Umeå university

    Författare :Anna Nilsson; Per-Arne Oldenborg; Karl-Eric Magnusson; [2009]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; macrophages; dendritic cells; phagocytosis; apoptotic cells; senescent erythrocytes; CD47; SIRPalpha; LRP1; calreticulin; NATURAL SCIENCES Biology Cell and molecular biology Immunology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Immunologi; immunologi; Immunology;

    Sammanfattning : Efficient removal of apoptotic cells is critical for development, tissue remodelling, maintenance of homeostasis, and response to injury. Phagocytosis of apoptotic cells is mediated by many phagocytic receptors, soluble bridging molecules, and pro-phagocytic ligands on the surface of apoptotic cells. LÄS MER

  4. 4. Phagocytosis by neutrophils - studies on phagosome dynamics and membrane traffic modulation by Streptococcus pyogenes

    Detta är en avhandling från Lund University

    Författare :Pontus Nordenfelt; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fluorescence microscopy; membrane traffic; neutrophil; Streptococcus pyogenes; phagosome; phagocytosis;

    Sammanfattning : Neutrophils are our most numerous and deadly white blood cells and without them we would succumb quickly to infections by pathogens. The main mechanism that the neutrophils employ for our protection is phagocytosis, where they eat and enclose their target inside a membrane-bound organelle, the phagosome. LÄS MER

  5. 5. Glucose and insulin modulate phagocytosis and production of reactive oxygen metabolites in human neutrophil granulocytes

    Detta är en avhandling från Umeå : Integrativ medicinsk biologi

    Författare :Daniel Saiepour; Per-Arne Oldenborg; Janove Sehlin; Olle Stendahl; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophil granulocytes; glucose; insulin; protein kinase C; diacylglycerol; phagocytosis; respiratory burst; diabetes; MEDICINE Morphology; cell biology; pathology Morphology Histology; MEDICIN Morfologi; cellbiologi; patologi Morfologi Histologi;

    Sammanfattning : Neutrophil granulocytes play an important role in the host defence against invading microorganisms and constitute the frontline of defence within the innate immune system and are among the first cells to arrive at the site of inflammation. Effective phagocytosis and killing of invading pathogens by neutrophils is of significant importance for successful resistance to infectious diseases. LÄS MER