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Visar resultat 1 - 5 av 97 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Selection and design in antibody phage display

    Författare :Jonas Persson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; specificity fine-tuning.; phage display; MUC1; automated selection; antigenicity; antibody; affinity maturation;

    Sammanfattning : The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. LÄS MER

  3. 2. The biology of filamentous phage infection - implications for display technology

    Författare :Fredrik Karlsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biotechnology; Bioteknik; infection mechanism; selective infection; TolA; Escherichia coli; pIII; Filamentous phage; Phage display technology;

    Sammanfattning : Phage display technology is a biotechnological tool that can be used to obtain molecules/reagents able to discriminate between target molecules. Reagents with such features can be used in diverse settings like biological chemistry, diagnostics and in therapeutic applications. LÄS MER

  4. 3. Ribosome display for selection and evolution of affibody molecules

    Författare :Sebastian Grimm; Per-Åke Nygren; Mike Taussig; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Sammanfattning : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. LÄS MER

  5. 4. Discovery of targets for tumor immunotherapy using phage display technology

    Författare :Jesper Tordsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serology; Immunology; colon cancer; melanoma; tumor immunotherapy; phage display; scFv; Immunologi; serologi; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : This thesis has focused on the development of methods and their applications for the identification of antibodies reactive with tumor associated antigens (TAA). The phage display technology provides a powerful mean to generate antibodies potentially useful for tumor immunotherapy. LÄS MER

  7. 5. Towards novel applications for biomolecular interactions at surfaces

    Författare :Pernilla Söderberg; Karl Hult; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molecular recognition; interactions; phage display; biomolecular interactions; phage; adenine; influenza virus replication; oseltamivir; imprinted polymers.;

    Sammanfattning : The focus of this thesis has been to examine two new concepts involving the interaction of biological agents with synthetic material surfaces.The feasibility of deploying phage display techniques for the screening of materials in non-biological media was examined in two studies. LÄS MER