Sökning: "pgc-1alpha"

Hittade 5 avhandlingar innehållade ordet pgc-1alpha.

  1. 1. Effects of exercise and amino acid intake on mechanisms regulating protein synthesis and breakdown in human muscle

    Författare :Marcus Moberg; Eva Blomstrand; Hans-Christer Holmberg; Jørgen Jensen; Gymnastik- och idrottshögskolan; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Resistance exercise; concurrent exericse; leucine; BCAA; mTORC1 signaling; protein synthesis; MuRF-1; PGC-1alpha; Medicin Teknik; Medicine Technology;

    Sammanfattning : Skeletal muscle adapts differently to specific modes of exercise, where resistance training results in muscle growth and endurance training induces mitochondrial biogenesis. These are results of molecular events that occur after each exercise session, increasing the expression of specific genes and the rate of both synthesis and breakdown of protein. LÄS MER

  2. 2. Exercise and regulation of mitochondrial biogenesis factors in human skeletal muscle

    Författare :Jessica Norrbom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Regular physical activity has many positive implications on health and performance, such as lowered risk for premature death, improved glucose metabolism and cardiovascular function as well as endurance capacity. Even a single bout of exercise is enough stimulus to change expression of many skeletal muscle genes. LÄS MER

  3. 3. Gene expression in human skeletal muscle : Effects of activity, fibre type and inheritance for diabetes

    Författare :Maria Ahlsén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Skeletal muscle; first-degree relatives; type 2 diabetes; spinal cord injury; exercise; AMPK; PPAR; PGC-1;

    Sammanfattning : One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin resistance are for example obesity, surgery, severe illness, spinal cord injury, and pregnancy. LÄS MER

  4. 4. Genes predisposing to type 2 diabetes and cardiovascular mortality

    Författare :Jenny Fredriksson; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; APM1; PPARG; PPARGC1A; survival abalysis; Medicin människa och djur ; Medicine human and vertebrates ; Type 2 Diabetes; cardiovascular mortality; glycogen synthase; adiponectin; GYS1;

    Sammanfattning : Cardiovascular complications are frequent in type 2 diabetes (T2D) and cardiovascular death is the most common cause of death for these individuals. A region on chromosome 19 (19q13) has been indicated by several genome scans as a susceptibility locus for T2D or components of the metabolic syndrome (MetS). LÄS MER

  5. 5. Peroxisome proliferator-activated receptor delta : regulation of skeletal muscle metabolism

    Författare :David Kitz Krämer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Peroxisome Proliferator-Activated Receptor PPAR 4 insulin sensitivity; insulin action; human skeletal muscle; primary cultured muscle cells; lipid-metabolism; glucose metabolism; AMP activated protein kinase AMPK ; Type 2 Diabetes Mellitus;

    Sammanfattning : Peroxisome Proliferator-Activated Receptor (PPAR) δ is a nuclear transcription factor which has been implicated in the regulation of lipid metabolism in skeletal muscle. In addition to the postural and locomotive functions of skeletal muscle, this organ has a major impact role on whole body metabolism. LÄS MER