Sökning: "pfkfb3"

Hittade 3 avhandlingar innehållade ordet pfkfb3.

1. 1. Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition

   Författare :Jemina Lehto; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies in the DNA damage response. LÄS MER

3. 2. Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer

   Författare :Anna Huguet Ninou; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues limit the therapeutic potential of such therapies. LÄS MER

4. 3. Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets

   Författare :Nadilly Y Bonagas Villarreal; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Altered tumor metabolism has been described as early as the 1920s, but it was only in recent decades that proteomic and metabolomic studies revealed that the ways in which tumors rewire their nutrient and energy pathways are more diverse and have more implications for treatment outcome than previously thought. There is now a great interest in characterizing promising metabolic targets and identifying novel ways by which to exploit them for cancer treatment. LÄS MER